SchizConnect: Virtual Data Integration in Neuroimaging

  • Jose Luis Ambite
  • Marcelo Tallis
  • Kathryn Alpert
  • David B. Keator
  • Margaret King
  • Drew Landis
  • George Konstantinidis
  • Vince D. Calhoun
  • Steven G. Potkin
  • Jessica A. Turner
  • Lei Wang
Conference paper

DOI: 10.1007/978-3-319-21843-4_4

Part of the Lecture Notes in Computer Science book series (LNCS, volume 9162)
Cite this paper as:
Ambite J.L. et al. (2015) SchizConnect: Virtual Data Integration in Neuroimaging. In: Ashish N., Ambite JL. (eds) Data Integration in the Life Sciences. DILS 2015. Lecture Notes in Computer Science, vol 9162. Springer, Cham

Abstract

In many scientific domains, including neuroimaging studies, there is a need to obtain increasingly larger cohorts to achieve the desired statistical power for discovery. However, the economics of imaging studies make it unlikely that any single study or consortia can achieve the desired sample sizes. What is needed is an architecture that can easily incorporate additional studies as they become available. We present such architecture based on a virtual data integration approach, where data remains at the original sources, and is retrieved and harmonized in response to user queries. This is in contrast to approaches that move the data to a central warehouse. We implemented our approach in the SchizConnect system that integrates data from three neuroimaging consortia on Schizophrenia: FBIRN’s Human Imaging Database (HID), MRN’s Collaborative Imaging and Neuroinformatics System (COINS), and the NUSDAST project at XNAT Central. A portal providing harmonized access to these sources is publicly deployed at schizconnect.org.

Keywords

Data integration Neuroimaging Mediation Schema mappings 

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Jose Luis Ambite
    • 1
  • Marcelo Tallis
    • 1
  • Kathryn Alpert
    • 2
  • David B. Keator
    • 3
  • Margaret King
    • 4
  • Drew Landis
    • 4
  • George Konstantinidis
    • 1
  • Vince D. Calhoun
    • 4
    • 5
  • Steven G. Potkin
    • 3
  • Jessica A. Turner
    • 4
    • 6
  • Lei Wang
    • 2
  1. 1.University of Southern CaliforniaLos AngelesUSA
  2. 2.Northwestern UniversityChicagoUSA
  3. 3.University of CaliforniaIrvineUSA
  4. 4.Mind Research NetworkAlbuquerqueUSA
  5. 5.University of New MexicoAlbuquerqueUSA
  6. 6.Georgia State UniversityAtlantaUSA

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