Dendritic Nanomaterials for Therapeutic and Diagnostic Applications

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Part of the Biosystems & Biorobotics book series (BIOSYSROB, volume 9)

Abstract

Dendritic nanomaterials have attracted a great deal of scientific interest for use in various biomedical applications primarily due to their well-defined structure and capacity for multifunctionalization. In this chapter, we present a comprehensive overview of the recent advances in various dendrimers and their modified dendritic materials with a particular focus on their applications such as drug delivery, gene delivery, diagnostics and prognostics, and detoxification/prophylaxis. We also discuss the fundamentals of the biological interactions of dendritic nanomaterials in regard to non-specific cell interactions, multivalent binding, stimuli-responsive processes, and biodistribution. In addition, this chapter highlights the current drawbacks of dendrimers that have hindered their rapid clinical translation and introduce recent approaches to overcoming these challenges.

Keywords

Block Copolymer Gene Delivery Bacterial Vaginosis PAMAM Dendrimers Diagnostic Application 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Biopharmaceutical Sciences, College of PharmacyUniversity of IllinoisChicagoUSA

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