Tendon Stem Cell Niche

  • Raquel Costa-Almeida
  • A. I. Gonçalves
  • P. Gershovich
  • M. T. Rodrigues
  • R. L. Reis
  • M. E. Gomes
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Tendon stem cells constitute a heterogeneous population of stem and progenitor cells that is involved in tendon formation and healing. The basic understanding of the interactions between tendon cells and their surroundings can enable the development of improved regenerative therapies. In this chapter, the main characteristics of their microenvironment—niche—are reviewed. In particular, the importance of signaling molecules and extracellular matrix (ECM) are highlighted, focusing on their potential role in tendon regeneration.

Keywords

Cell therapy Extracellular matrix Niche Regenerative medicine Tendon healing/repair Tendon stem/progenitor cells Tenogenesis 

Abbreviations

α-SMA

Alpha smooth muscle actin

BMSCs

Bone marrow-derived mesenchymal stem cells

CD

Cluster of differentiation

COMP

Collagen oligomeric matrix protein

Cx

Connexin

ECM

Extracellular matrix

Egr 1

Early growth response 1 transcription factor

Egr 2

Early growth response 2 transcription factor

EGF

Epidermal growth factor

FGF

Fibroblast growth factor

GAGs

Glycosaminoglycans

GDF-5

Growth differentiation factor 5

GFs

Growth factors

IGF

Insulin-like growth factor

MHC-II

Major histocompatibility complex II

Mkx

Mohawk

MSCs

Mesenchymal stem cells

PDGF-BB

Platelet derived growth factor

PLs

Platelet lysates

PGs

Proteoglycans

PRP

Platelet-rich plasma

Scx

Scleraxis

TGF-β

Transforming growth factor-beta

TDSCs

Tendon-derived stem cells

TFs

Transcription factors

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Raquel Costa-Almeida
    • 1
    • 2
  • A. I. Gonçalves
    • 1
    • 2
  • P. Gershovich
    • 1
    • 2
  • M. T. Rodrigues
    • 1
    • 2
  • R. L. Reis
    • 1
    • 2
  • M. E. Gomes
    • 1
    • 2
  1. 1.3B’s Research Group, Biomaterials, Biodegradables and BiomimeticsUniversity of MinhoGuimarãesPortugal
  2. 2.ICVS/3B’s Government Associate LaboratoryUniversity of MinhoBragaPortugal

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