Tendon Stem Cell Niche

  • Raquel Costa-Almeida
  • A. I. Gonçalves
  • P. Gershovich
  • M. T. Rodrigues
  • R. L. Reis
  • M. E. GomesEmail author
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)


Tendon stem cells constitute a heterogeneous population of stem and progenitor cells that is involved in tendon formation and healing. The basic understanding of the interactions between tendon cells and their surroundings can enable the development of improved regenerative therapies. In this chapter, the main characteristics of their microenvironment—niche —are reviewed. In particular, the importance of signaling molecules and extracellular matrix (ECM) are highlighted, focusing on their potential role in tendon regeneration.


Cell therapy Extracellular matrix Niche Regenerative medicine Tendon healing/repair Tendon stem/progenitor cells Tenogenesis 



Alpha smooth muscle actin


Bone marrow-derived mesenchymal stem cells


Cluster of differentiation


Collagen oligomeric matrix protein




Extracellular matrix

Egr 1

Early growth response 1 transcription factor

Egr 2

Early growth response 2 transcription factor


Epidermal growth factor


Fibroblast growth factor




Growth differentiation factor 5


Growth factors


Insulin-like growth factor


Major histocompatibility complex II




Mesenchymal stem cells


Platelet derived growth factor


Platelet lysates




Platelet-rich plasma




Transforming growth factor-beta


Tendon-derived stem cells


Transcription factors


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Raquel Costa-Almeida
    • 1
    • 2
  • A. I. Gonçalves
    • 1
    • 2
  • P. Gershovich
    • 1
    • 2
  • M. T. Rodrigues
    • 1
    • 2
  • R. L. Reis
    • 1
    • 2
  • M. E. Gomes
    • 1
    • 2
    Email author
  1. 1.3B’s Research Group, Biomaterials, Biodegradables and BiomimeticsUniversity of MinhoGuimarãesPortugal
  2. 2.ICVS/3B’s Government Associate LaboratoryUniversity of MinhoBragaPortugal

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