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Distribution of the Endocannabinoid System in the Central Nervous System

  • Sherry Shu-Jung Hu
  • Ken MackieEmail author
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 231)

Abstract

The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), the enzymes that synthesize and degrade endocannabinoids, and the receptors that transduce the effects of endocannabinoids. Much of what we know about the function of endocannabinoids comes from studies that combine localization of endocannabinoid system components with physiological or behavioral approaches. This review will focus on the localization of the best-known components of the endocannabinoid system for which the strongest anatomical evidence exists.

Keywords

CB1 cannabinoid receptor Immunocytochemistry In situ hybridization 

Abbreviations

2-AG

2-Arachidonoylglycerol

ABHD4/6/12

α/β-hydrolase domain 4/6/12

AEA or anandamide

N-arachidonoylethanolamine

BLA

Basolateral amygdala

CB1 and CB2

Cannabinoid receptor 1 and 2

CRIP1a

Cannabinoid receptor interacting protein 1a

DAGLα/β

Diacylglycerol lipase α/β

DRG

Dorsal root ganglion

FAAH

Fatty acid amide hydrolase

GDE1

Glycerophosphodiesterase 1

M1

Muscarinic cholinergic receptor

MAGL

Monoacylglycerol lipase

mGluR5

Metabotropic glutamate receptor 5

MSNs

Striatal medium spiny neurons

NAAA

N-acylethanolamine-hydrolyzing acid amidase

NAPE-PLD

N-acyl phosphatidylethanolamine phospholipase D

PAG

Periaqueductal gray

SN

Substantia nigra

TH

Tyrosine hydroxylase

VTA

Ventral tegmental area

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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of PsychologyNational Cheng Kung UniversityTainanTaiwan
  2. 2.Department of Psychological and Brain SciencesIndiana UniversityBloomingtonUSA
  3. 3.Gill Center for Biomolecular ScienceIndiana UniversityBloomingtonUSA

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