Left and Right Atrial Contribution to the P-wave in Realistic Computational Models

  • Axel Loewe
  • Martin W. Krueger
  • Pyotr G. Platonov
  • Fredrik Holmqvist
  • Olaf Dössel
  • Gunnar Seemann
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9126)


ECG markers derived from the P-wave are used frequently to assess atrial function and anatomy, e.g. left atrial enlargement. While having the advantage of being routinely acquired, the processes underlying the genesis of the P-wave are not understood in their entirety. Particularly the distinct contributions of the two atria have not been analyzed mechanistically. We used an in silico approach to simulate P-waves originating from the left atrium (LA) and the right atrium (RA) separately in two realistic models.

LA contribution to the P-wave integral was limited to 30 % or less. Around 20 % could be attributed to the first third of the P-wave which reflected almost only RA depolarization. Both atria contributed to the second and last third with RA contribution being about twice as large as LA contribution. Our results foster the comprehension of the difficulties related to ECG-based LA assessment.


Atrial modeling Electrocardiogram P-wave Mathematical modeling Left atrial enlargement 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Axel Loewe
    • 1
  • Martin W. Krueger
    • 1
    • 2
  • Pyotr G. Platonov
    • 3
    • 4
  • Fredrik Holmqvist
    • 3
    • 4
  • Olaf Dössel
    • 1
  • Gunnar Seemann
    • 1
  1. 1.Institute of Biomedical EngineeringKarlsruhe Institute of Technology (KIT)KarlsruheGermany
  2. 2.ABB Corporate ResearchLadenburgGermany
  3. 3.Department of Cardiology and The Center for Integrative Electrocardiology (CIEL)Lund UniversityLundSweden
  4. 4.Department of CardiologySkåne University HospitalLundSweden

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