A Framework for Determination of Heart Valves’ Mechanical Properties Using Inverse-Modeling Approach
Heart valves play a very important role in the functioning of the heart and many of the heart failures are related to the valvular dysfunctions, e.g. aortic stenosis and mitral regurgitation. Relationship between the biomechanical properties of valve leaflets and their function has long been established, however, determining these properties in a non-invasive manner remains a challenge. Here we present a framework for such a tool for biomechanical properties determination. We use an inverse-modeling approach, where the only input is through imaging the leaflet tissue as it is loaded naturally during its functional cycle. Using a structural model for the leaflet material behavior allows us to reduce the number of parameters to be determined to only two, which in addition to dramatically reducing the computational time also allows one to visualize the cost function and the minimization process. We close with discussion about the contributions of the current framework and other constituents needed to make it a clinically viable tool.
KeywordsCost Function Heart Valve Inverse Model Prosthetic Valve Valve Leaflet
We gratefully acknowledge the help from Will Zhang with parameter estimation and analysis of biaxial data. This work was supported by NIH Grant HL108330 and Moncrief Chair funds (M.S.S.) and American Heart Association Postdoctoral Fellowship 14POST18720037 (A.A.). The authors acknowledge the Texas Advanced Computing Center at The University of Texas at Austin for providing HPC resources.
- 9.Xi, J., Lamata, P., Niederer, S., Land, S., Shi, W., Zhuang, X., Ourselin, S., Duckett, S.G., Shetty, A.K., Rinaldi, C.A., Rueckert, D., Razavi, R., Smith, N.P.: The estimation of patient-specific cardiac diastolic functions from clinical measurements. Med. Image Anal. 17(2), 133–146 (2013)CrossRefGoogle Scholar
- 10.Aggarwal, A., Aguilar, V.S., Lee, C.H., Ferrari, G., Gorman, J.H., Gorman, R.C., Sacks, M.S.: Patient-specific modeling of heart valves: from image to simulation. In: Ourselin, S., Rueckert, D., Smith, N. (eds.) FIMH 2013. LNCS, vol. 7945, pp. 141–149. Springer, Heidelberg (2013) CrossRefGoogle Scholar