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Personalization of Atrial Electrophysiology Models from Decapolar Catheter Measurements

  • Cesare CorradoEmail author
  • Steven Williams
  • Henry Chubb
  • Mark O’Neill
  • Steven A. Niederer
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9126)

Abstract

A novel method to characterize biophysical atria regional ionic models from multi-electrode catheter measurements and tailored pacing protocols is presented. Local atria electrophysiology was described by the Mitchell and Schaeffer 2003 action potential model. The pacing protocol was evaluated using simulated bipolar signals from a decapolar catheter in a model of atrial tissue. The protocol was developed to adhere to the constraints of the clinical stimulator and extract the maximum information about local electro-physiological properties solely from the time the activation wave reaches each electrode. Parameters were fitted by finding the closest parameter set to a data base of 3125 pre computed solutions each with different parameter values. This fitting method was evaluated using 243 randomly generated in silico data sets and yielded a mean error of \(\pm 10.46\,\%\) error in estimating model parameters.

Keywords

Electrograms Computational models personalization Multi-electrode catheters 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Cesare Corrado
    • 1
    Email author
  • Steven Williams
    • 1
  • Henry Chubb
    • 1
  • Mark O’Neill
    • 1
  • Steven A. Niederer
    • 1
  1. 1.Division of Imaging Sciences and Biomedical EngineeringKing’s College LondonLondonUK

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