T- and NK-Cell Lymphocytosis

  • Sa A. WangEmail author


Peripheral blood (PB) lymphocytosis is one of the most common abnormalities encountered in clinical hematology laboratory. Lymphocytosis is an increase in the number and/or proportion of lymphocytes in the blood. The normal ranges of lymphocytes in adult patients are about 1.0–3.0 × 109/L and 20–40%. In adults, absolute lymphocytosis is defined as absolute lymphocyte count (ALC) greater than 4.0 × 109/L, while relative lymphocytosis is an increase in the percentage of lymphocytes >40%, but ALC is normal. In children, the reference ranges differ significantly with age and, in general, significantly higher than adults. Mayo Clinic laboratory data reported a normal range of lymphocyte count of 2.0–11.0 × 109/L (26–36%) at birth, which increases over the first 6 months of life, and peaks at 6 months to 1 year 1.4–22 × 109/L (47–77%), then declines over time, and approaches to adult range between age 15 and 20 years. The reference ranges may vary depending on populations, individual laboratory, instruments, and methods.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of HematopathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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