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Microbiome to Brain: Unravelling the Multidirectional Axes of Communication

  • Sahar El Aidy
  • Roman Stilling
  • Timothy G. Dinan
  • John F. CryanEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 874)

Abstract

The gut microbiome plays a crucial role in host physiology. Disruption of its community structure and function can have wide-ranging effects making it critical to understand exactly how the interactive dialogue between the host and its microbiota is regulated to maintain homeostasis. An array of multidirectional signalling molecules is clearly involved in the host-microbiome communication. This interactive signalling not only impacts the gastrointestinal tract, where the majority of microbiota resides, but also extends to affect other host systems including the brain and liver as well as the microbiome itself. Understanding the mechanistic principles of this inter-kingdom signalling is fundamental to unravelling how our supraorganism function to maintain wellbeing, subsequently opening up new avenues for microbiome manipulation to favour desirable mental health outcome.

Keywords

Microbiota Gut-brain axis Immune system Metabolites Epigenetics 

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Sahar El Aidy
    • 1
  • Roman Stilling
    • 2
    • 3
  • Timothy G. Dinan
    • 2
    • 4
  • John F. Cryan
    • 2
    • 3
    Email author
  1. 1.Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology InstituteUniversity of GroningenGroningenThe Netherlands
  2. 2.Laboratory of Neurogastroenterology, Alimentary Pharmabiotic CentreUniversity College CorkCorkIreland
  3. 3.Department of Anatomy and NeuroscienceUniversity College CorkCorkIreland
  4. 4.Department of PsychiatryUniversity College CorkCorkIreland

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