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Group Testing for Longitudinal Data

  • Yi HongEmail author
  • Nikhil Singh
  • Roland Kwitt
  • Marc Niethammer
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9123)

Abstract

We consider how to test for group differences of shapes given longitudinal data. In particular, we are interested in differences of longitudinal models of each group’s subjects. We introduce a generalization of principal geodesic analysis to the tangent bundle of a shape space. This allows the estimation of the variance and principal directions of the distribution of trajectories that summarize shape variations within the longitudinal data. Each trajectory is parameterized as a point in the tangent bundle. To study statistical differences in two distributions of trajectories, we generalize the Bhattacharyya distance in Euclidean space to the tangent bundle. This not only allows to take second-order statistics into account, but also serves as our test-statistic during permutation testing. Our method is validated on both synthetic and real data, and the experimental results indicate improved statistical power in identifying group differences. In fact, our study sheds new light on group differences in longitudinal corpus callosum shapes of subjects with dementia versus normal controls.

Keywords

Longitudinal data Distribution of trajectories Tangent bundle Group testing Bhattacharyya distance 

Notes

Acknowledgements

This work was supported by NSF EECS-1148870 and NSF EECS-0925875.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Yi Hong
    • 1
    Email author
  • Nikhil Singh
    • 1
  • Roland Kwitt
    • 2
  • Marc Niethammer
    • 1
  1. 1.Department of Computer ScienceUNC Chapel HillChapel HillUSA
  2. 2.Department of Computer ScienceUniversity of SalzburgSalzburgAustria

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