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Mechanisms of Recurrent Chromosomal Translocations

  • Richard L. Frock
  • Jiazhi Hu
  • Frederick W. Alt

Abstract

Chromosomal translocations frequently involve fusion of the ends of two separate DNA double-stranded breaks (DSBs) at distinct genomic locations. Recurrent chromosomal translocations are found in various cancers. Recently developed high-throughput approaches to clone genome-wide translocations that involve site-specific DSBs have provided new insights into mechanisms of chromosomal translocations. Such studies confirmed that, beyond cellular selection forces, basic mechanistic factors, including DSB frequency and persistence, as well as aspects of three dimensional genome organization, can contribute to recurrent translocations in a cell population. This review discusses our current view of the contribution of such mechanistic factors to recurrent chromosomal translocations.

Keywords

Chromosomal translocations Genomic instability Lymphocyte development DNA breaks DNA repair 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Richard L. Frock
    • 1
  • Jiazhi Hu
    • 1
  • Frederick W. Alt
    • 1
  1. 1.Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, and Department of GeneticsHarvard Medical SchoolBostonUSA

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