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A Preliminary Assessment of Three Strategies for the Agent-Based Modeling of Bacterial Conjugation

  • Antonio Prestes GarcíaEmail author
  • Alfonso Rodríguez-Patón
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 375)

Abstract

Bacterial conjugation is a cell-cell communication by which neighbor cells transmit circular DNA strands called plasmids. The transmission of these plasmids has been traditionally modeled using differential equations. Recently agent-based systems with spatial resolution have emerged as a promising tool that we use in this work to assess three different schemes for modeling the bacterial conjugation. The three schemes differ basically in which point of cell cycle the conjugation is most prone to happen. One alternative is to allow a conjugative event occurs as soon a suitable recipient is found, the second alternative is to make conjugation equally like to happen throughout the cell cycle and finally, the third one technique to assume that conjugation is more likely to occur in a specific point late in the cell cycle.

Keywords

Agent-based modeling Individual-based modeling Plasmids Bacterial conjugation Synthetic biology 

Notes

Acknowledgments

This work was supported by the European FP7-ICT-FET EU research project 612146 (PLASWIRES “Plasmids as Wires” project) www.plaswires.eu and by Spanish Government (MINECO) research grant TIN2012-36992.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Antonio Prestes García
    • 1
    Email author
  • Alfonso Rodríguez-Patón
    • 1
  1. 1.Departamento de Inteligencia ArtificialUniversidad Politécnica de Madrid, Campus de Montegancedo s/nMadridSpain

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