Nature-Inspired Multifunctional Host Defense Peptides with Dual Antimicrobial-Immunomodulatory Activities

  • Jasmeet Singh Khara
  • Pui Lai Rachel EeEmail author


Naturally occurring antimicrobial peptides (AMPs) have been proposed as blueprints for the development of new antimicrobials to combat the widespread emergence of bacterial resistance. Though early work in the field has predominantly focused on their broad-spectrum antimicrobial activity, mounting evidence suggests that the immunomodulating properties of these innate defense molecules may be as critical for their development into potent therapeutic agents. In this chapter, the biological activities of both natural and synthetic multifunctional host defense peptides (HDPs) are discussed, with a focus on design strategies aimed at bestowing these molecules with superior antimicrobial and immune-regulating properties, their potential clinical applications, and challenges hampering the transition of these therapeutic agents from the benchtop to the clinic.


Antimicrobial peptides Host defense peptides Immunomodulatory peptides Anti-inflammatory Cathelicidins Defensins Peptide conjugates Hybrid peptides Peptidomimetics Peptide congeners 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of PharmacyNational University of SingaporeSingaporeSingapore

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