Diet and Personalized Medicine

Chapter
Part of the SpringerBriefs in Space Development book series (BRIEFSSPACE)

Abstract

Researchers have found that astronauts who suffered vision changes had lower serum folate and higher concentrations of homocysteine, cystathionine, 2-methyl citric acid, and methyl malonic acid than crewmembers who did not report visual deficits. The vision impairment problem is a multi-faceted issue that is characterized by significant intra-individual variation. Perhaps the answer lies in personalized medicine, or Omics.

Keywords

Personalized Medicine Sodium Intake International Space Station Idiopathic Intracranial Hypertension MTHFR C677T 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Zwart SR, Gibson CR, Mader TH, Ericson K, Ploutz-Snyder R, Heer M, Smith SM. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. Journal of Nutrition. 2012;142:427–31.CrossRefPubMedGoogle Scholar
  2. 2.
    Martin-Amat G, McMartin KE, et al. Methanol poisoning: Ocular toxicity produced by formate. Toxicol Applied Pharmacology. 1978;45:201–208. 6.Google Scholar
  3. 3.
    Sadun A. Acquired mitochondrial impairment as a cause of optic nerve disease. Trans Am Ophthalmol Soc. 1998;96:881–923.PubMedCentralPubMedGoogle Scholar
  4. 4.
    Stamler, J. The INTERSALT Study: background, methods, findings, and implications. American Journal of Clinical Nutrition 65 (1997): 6265–6425.Google Scholar
  5. 5.
    Vollmer WM., et al. Effects of diet and sodium intake on blood pressure: Subgroup analysis of the DASH-Sodium Trial. Annals of Internal Medicine 135 (2001): 1019–1028.CrossRefPubMedGoogle Scholar
  6. 6.
    Bekavac I, Goel S. Transient, unilateral, complete, oculomotor palsy in an adult patient with idiopathic intracranial hypertension. Signa Vitae 6, no. 1 (2011): 44–46.Google Scholar
  7. 7.
    Newborg B. Pseudotumor cerebri treated by rice reduction diet. Arch Intern Med 133 (1974): 802–807.CrossRefPubMedGoogle Scholar
  8. 8.
    Wall M, McDermott MP, Kieburtz KD, Corbett JJ, Feldon SE, Friedman DI, Keltner JL, Schron EB, Kupersmith MJ. Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. JAMA. 2014 Apr 23–30;311(16):1641–51.Google Scholar
  9. 9.
    Fredriksen, A, K Meyer, PM Ueland, SE Vollset, T Grotmol, and J Schneede. Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat 28, no. 9 (2007): 856–865.CrossRefPubMedGoogle Scholar
  10. 10.
    Shane, B. Folate chemistry and metabolism. In Folate in health and disease, by LB Bailey, 1–22. New York: Marcel Dekker, 1995.Google Scholar
  11. 11.
    Smith SM, Zwart SR, Gregory JF, Poutz-Snyder R. Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism. Human Health and Countermeasures Element, NASA Human Research Program, 2011.Google Scholar
  12. 12.
    Ozdek S, Yulek F, Gurelik G, Aydin B, Hasanreisoglu B. Simultaneous central retinal vein and retinal artery branch occlusions in two patients with homocystinaemia. Eye (Lond). 2004;18:942–5.CrossRefGoogle Scholar
  13. 13.
    Schmidt MA, Goodwin TJ. Personalized medicine in human space flight: using Omics based analyses to develop individualized countermeasures that enhance astronaut safety and performance. Metabolomics (2013) 9:1134–1156.Google Scholar
  14. 14.
    Tanaka, H. Omics-based medicine and systems pathology: A new perspective for personalized and predictive medicine. Methods of Information in Medicine (2010), 49, 173–185.Google Scholar
  15. 15.
    Mader TH, Gibson CR, Pass AF. et al. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology (2011), 118, 2058–2069.Google Scholar
  16. 16.
    Mader TH, Gibson CR, Pass AF. Regarding diurnal pattern of intraocular pressure is affected by microgravity when measured in space with the pressure phosphene tonometer. Journal of Glaucoma (2012), 21(5), 349–350.CrossRefPubMedGoogle Scholar
  17. 17.
    Gibson CR, Mader TH, Schallhorn SC, et al. Visual stability of laser vision correction in an astronaut on a Soyuz mission to the International Space Station. Journal of Cataract and Refractive Surgery (2012), 38(8), 1486–1491.CrossRefPubMedGoogle Scholar
  18. 18.
    Ganapathy PS, White RE, Ha Y., et al. The role of Nmethyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells. Investigative Ophthalmology & Visual Science (2011), 52, 5515–5524.Google Scholar
  19. 19.
    Kesler A, Kliper E, Assayag EB, et al. Thrombophilic factors in idiopathic intracranial hypertension: A report of 51 patients and a meta-analysis. Blood Coagulation & Fibrinolysis (2010), 21, 328–333.Google Scholar
  20. 20.
    Wilson CP, Ward M, McNulty H., et al. Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up. American Journal of Clinical Nutrition (2012), 95, 766–772.Google Scholar
  21. 21.
    Zwart SR, Gibson CR, Mader TH., et al. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. Journal of Nutrition (2010), 142, 427–431.Google Scholar
  22. 22.
    Zwart SR, Morgan JL, Smith SM. Iron status and its relations with oxidative damage and bone loss during long duration space flight on the International Space Station. The American Journal of Clinical Nutrition (2013), doi:10.3945/ajcn. 112.056465.Google Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Manned Spaceflight ConsultantSandefjordNorway

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