The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium

  • Daniel G. Taub
  • Qin LiuEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 854)


The photoreceptor is a complex specialized cell in which a major component responsible for visual transduction is the photoreceptor sensory cilium (PSC). Building and maintenance of the PSC requires the transport of large proteins along microtubules that extend from the inner segments to the outer segments. A key process, termed intraflagellar transport (IFT), has been recognized as an essential phenomenon for photoreceptor development and maintenance, and exciting new studies have highlighted its importance in retinal and cilia related diseases. This review focuses on the important roles of IFT players, including motor proteins, IFT proteins, and photoreceptor-specific cargos in photoreceptor sensory cilium. In addition, specific IFT components that are involved in inherited human diseases are discussed.


Inherited retinal degeneration Intraflagellar transport (IFT) Cilia Photoreceptor Protein transport 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Ocular Genomics Institute, and Berman-Gund Laboratory for the Study of Retinal Degenerations, Department of OphthalmologyMassachusetts Eye and Ear Infirmary, Harvard Medical SchoolBostonUSA

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