Protein Contact Prediction by Integrating Joint Evolutionary Coupling Analysis and Supervised Learning

Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9029)


Residue-residue contacts play an important role in maintaining the native fold of a protein and guiding protein folding. However, contact prediction from sequence is very challenging, as indicated by CASP10 [1], which shows that long-range contact prediction accuracy on hard targets is only ~20%.


Random Forest Supervise Learning Method Pfam Family Gaussian Graphical Model Contact Prediction 
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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Jianzhu Ma
    • 1
  • Sheng Wang
    • 1
  • Zhiyong Wang
    • 1
  • Jinbo Xu
    • 1
  1. 1.Toyota Technological Institute at ChicagoChicagoUSA

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