Multisite Monitoring of NADH

  • Avraham Mayevsky
Chapter

Abstract

Most of the NADH monitoring in the 1960s and 1970s was done at a single point in one organ. To investigate complicated anatomical and physiological issues related to mitochondrial function and dysfunction, it was necessary to develop the technology, and two approaches were used. To compare four points in the same organ or in four organs in the same animal and in real time, a multichannel fluorometer was developed. The second approach was to have 2-D or 3-D mapping of NADH in a single organ without temporal resolution. Later on, we developed a multisite and multiparametric approach that provided better understanding of pathophysiological events in the brain or the intact body in real time. The main techniques that were developed and typical results are described in this chapter.

Keywords

Multisite monitoring of NADH Low-temperature scanning of NADH Two-site monitoring of heart Multiorgan monitoring in vivo NADH in spreading depression wave 
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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Avraham Mayevsky
    • 1
  1. 1.Faculty of Life SciencesBar-Ilan UniversityRamat-GanIsrael

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