Abstract
Aortic diseases are one relevant cause of death in Western countries. They involve significant alterations of the aortic wall tissue, with consequent changes in the stiffness, i.e., the capability of the vessel to vary its section secondary to blood pressure variations. In this paper, we propose a Bayesian approach to estimate the aortic stiffness and its spatial variation, exploiting patient-specific geometrical data non-invasively derived from computed tomography angiography (CTA) images. The proposed method is tested considering a real clinical case, and outcomes show good estimates and the ability to detect local stiffness variations. The final objective is to support the adoption of imaging techniques such as the CTA as a standard tool for large-scale screening and early diagnosis of aortic diseases.
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References
Dernellis, J., Panaretou, M.: Aortic stiffness is an independent predictor of progression to hypertension in non-hypertensive subjects. Hypertension 45, 426–431 (2005)
Gilioli, G., Pasquali, S., Ruggeri, F.: Bayesian analysis of a stochastic predator-prey model with nonlinear functional response. Math. Biosci. Eng. 9, 75–96 (2012)
Kloeden, P.E., Platen, E.: Numerical Solution of Stochastic Differential Equations. Springer, Berlin (1992)
Lanzarone, E., Liani, P., Baselli, G., Costantino, M.L.: Model of arterial tree and peripheral control for the study of physiological and assisted circulation. Med. Eng. Phys. 29, 542–555 (2007)
Lanzarone, E., Casagrande, G., Fumero, R., Costantino, M.L.: Integrated model of endothelial NO regulation and systemic circulation for the comparison between pulsatile and continuous perfusion. IEEE Trans. Bio-Med. Eng. 56, 1331–1340 (2009)
Lanzarone, E., Ruggeri, F.: Inertance estimation in a lumped-parameter hydraulic simulator of human circulation. J. Biomech. Eng. Trans. ASME 135, 061012 (2013)
Lanzarone, E., Pasquali, S., Mussi, V., Ruggeri, F.: Bayesian estimation of thermal conductivity and temperature profile in a homogeneous mass. Numer. Heat Transfer B Fund. 66, 397–421 (2014)
Oksendal, B.: Stochastic Differential Equations: An Introduction with Applications, 6th edn. Springer, Berlin (2003)
Pearson, A.C., Guo, R., Orsinelli, D.A., Binkley, P.F., Pasierski, T.J.: Transesophageal echocardiographic assessment of the effects of age, gender, and hypertension on thoracic aortic wall size, thickness, and stiffness. Am. Heart J. 128, 344–351 (1994)
Plummer, M.: JAGS: a program for analysis of Bayesian graphical models using Gibbs sampling. In: Proceedings of the 3rd International Workshop on Distributed Statistical Computing, Vienna, Austria (2003)
Quinn, U., Tomlinson, L.A., Cockcroft, J.R.: Arterial stiffness. J. Roy. Soc. Med. 1, 1–18 (2012)
Westerhof, N., Bosman, F., Vries, C.J.D., Noordergraaf, A.: Analog studies of the human systemic arterial tree. J. Biomech. 56, 121–143 (1969)
Yushkevich, P.A., Piven, J., Hazlett, H., Smith, R., Ho, J.G.S., Gerig, G.: User-guided 3d active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31, 1116–1128 (2006)
Acknowledgements
The authors acknowledge Flagship Project “Factory of the Future Fab@Hospital”, funded by Italian CNR and MIUR organizations. Michele Conti acknowledges ERC Starting Grant through the Project ISOBIO: Isogeometric Methods for Biomechanics (No. 259229).
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Lanzarone, E., Auricchio, F., Conti, M., Ferrara, A. (2015). Bayesian Estimation of the Aortic Stiffness based on Non-invasive Computed Tomography Images. In: Frühwirth-Schnatter, S., Bitto, A., Kastner, G., Posekany, A. (eds) Bayesian Statistics from Methods to Models and Applications. Springer Proceedings in Mathematics & Statistics, vol 126. Springer, Cham. https://doi.org/10.1007/978-3-319-16238-6_12
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DOI: https://doi.org/10.1007/978-3-319-16238-6_12
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