Uncertainty, Probabilistic Analysis and Outputs from Cost Effectiveness Analyses

  • Richard Edlin
  • Christopher McCabe
  • Claire Hulme
  • Peter Hall
  • Judy Wright

Abstract

An economic evaluation provides a summary of the current evidence for different actions in response to a decision problem, and aims to inform decision makers about what impacts these might have in terms of costs and benefits. As many of these costs and benefits occur in the future, and the future is inherently uncertain, it is important that economic evaluations explore the uncertainties in any answer that can be produced from current evidence. This chapter focuses on introducing the different sources of uncertainty in economic evaluation and the more straightforward mechanisms for their characterisations and analysis, along with a critical understanding of the limitations of these methods.

References

  1. Box GEP, Draper NR (1987) Empirical model building and response surfaces. Wiley, New YorkGoogle Scholar
  2. Brennan A, S C, Davies R (2006) A taxonomy of model structures for economic evaluation of health technologies. Health Econ 15(12):1295–1310PubMedCrossRefGoogle Scholar
  3. Briggs AH, Fenn P (1998) Confidence intervals or surfaces? Uncertainty on the cost-effectiveness plane. Health Econ 7(8):723–740PubMedCrossRefGoogle Scholar
  4. Caro JJ, Möller J, Getsios D (2010) Discrete event simulation: the preferred technique for health economic evaluations? Value Health 13(8):1056–1060. doi: 10.1111/j.1524-4733.2010.00775.x PubMedCrossRefGoogle Scholar
  5. Karlsson G, Johannesson M (1996) The decision rules of cost effectiveness analysis. Pharmacoeconomics 9(2):113–120PubMedCrossRefGoogle Scholar
  6. Karnon J (2003) Alternative decision modelling techniques for the evaluation of health care technologies: Markov processes versus discrete event simulation. Health Econ 10(12):837–848CrossRefGoogle Scholar
  7. Stinnett A, Mullahy J (1998) Net health benefits: a new framework for the analysis of uncertainty in cost effectiveness analysis. Med Decis Making 18(2-suppl):S68–S80PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Richard Edlin
    • 1
  • Christopher McCabe
    • 2
  • Claire Hulme
    • 3
  • Peter Hall
    • 4
  • Judy Wright
    • 3
  1. 1.Faculty of Medicine and Health SciencesUniversity of AucklandAucklandNew Zealand
  2. 2.Department of Emergency MedicineUniversity of AlbertaEdmontonCanada
  3. 3.Faculty of Medicine and HealthUniversity of LeedsLeedsUK
  4. 4.Edinburgh Cancer Research CentreUniversity of EdinburghEdinburghScotland, UK

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