Pathophysiology of Headaches pp 31-66

Part of the Headache book series (HEAD)

Animal Models of Migraine


The headache research field is privileged to have in its preclinical laboratories well-established animal models that significantly facilitate and improve our understanding of headache mechanisms, in particular in terms of the molecular signalling and brain networks involved. A variety of pharmacological screening approaches for novel therapeutics and for the improvement of advanced pharmacological agents can be achieved in translational research utilising these models. The available migraine models have been developed based on our understanding of migraine from clinical, migraine patient-specific evidence. These clinical phenotypes have been successfully employed to model features of the disease physiology in animals and to provide reproducible meaningful physiological measures in the laboratory.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Headache Research – Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of MedicineImperial College London, Chelsea and Westminster Hospital CampusLondonUK
  2. 2.National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaUSA

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