Taurine in 24-h Urine Samples Is Inversely Related to Cardiovascular Risks of Middle Aged Subjects in 50 Populations of the World
We previously showed that 24-h urinary taurine (Tau) excretion was inversely associated with mortality due to coronary heart diseases (CHD) and stroke. The aim of this study was to examine the association between 24-h urinary Tau/creatinine (Cre) ratio and cardiovascular disease risk factors, including body mass index (BMI), blood pressure (BP), serum total cholesterol (TC) and prevalence of obesity, hypertension and hypercholesterolemia.
A cross sectional analysis was conducted among 4,211 participants (2,120 men and 2,091 women) aged 48–56 from 50 population samples of 22 countries in the World Health Organization-coordinated Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study (1985–1994).
According to linear regression analyses adjusted for traditional risk factors such as age, sex and anti-hypertensive treatment, Tau/Cre was inversely associated with BMI, systolic BP, diastolic BP and TC (P for linear trend <0.001, respectively). These associations were not markedly altered by further adjustment for 24-h urinary sodium/Cre, potassium/Cre, calcium/Cre, magnesium/Cre and cohort effects. After adjusting for the traditional risk factors, the prevalence of obesity, hypertension and hypercholesterolemia among the subjects within the lowest quintile of the Tau/Cre ratio was 2.84 (95 % CI: 2.04, 3.96; P for trend <0.001), 1.22 (95 % CI: 0.98, 1.51; P < 0.05) and 2.20 (95 % CI: 1.73, 2.80; P < 0.001) times higher than that in the subjects within the highest quintile. These associations were not appreciably altered by further adjustment for other 24-h urinary markers and cohort effects.
In conclusion, higher Tau/Cre was associated with lower cardiovascular disease risk factors, including BMI, BP, TC, obesity, hypertension and hypercholesterolemia.
KeywordsTaurine 24-h Urine Cardiovascular disease risk factors Coronary heart disease Stroke Obesity Hypertension Hypercholesterolemia Cross-sectional studies Middle-aged
Coronary heart diseases
Body mass index
Cardiovascular Diseases and Alimentary Comparison
Spontaneously hypertensive rats
Cytochrome P450 7A1
This study was supported partly by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese government, and by donations to the WHO from over 300,000 individuals and companies in total, but had no relationship with industry. The authors thank all principal investigators and their colleagues in 50 study sites of the CARDIAC Study. All the authors report no conflicts of interest.
- Fukuda M, Yamori Y (1987) A proposal for indirect and objective blood pressure measurement in adults. In: Yamori Y, Lenfant C (eds) Prevention of cardiovascular diseases: an approach to active long life. Elsevier, Amsterdam, pp 127–137Google Scholar
- Gokce G, Ozsarlak-Sozer G, Oran I, Oktay G, Ozkal S, Kerry Z (2011) Taurine suppresses oxidative stress-potentiated expression of lectin-like oxidized low-density lipoprotein receptor and restenosis in balloon-injured rabbit iliac artery. Clin Exp Pharmacol Physiol 38:811–818CrossRefPubMedGoogle Scholar
- Iantorno M, Campia U, Di Damiele N, Nistico S, Forleo GB, Cardillo C, Tesauro M (2014) Obesity, inflammation and endothelial dysfunction. Int J Immunopathol Pharmacol 28:169–176Google Scholar
- McQueen MJ, Hawken S, Wang X, Ounpuu S, Sniderman A, Probstfield J, Steyn K, Sanderson JE, Hasani M, Volkova E, Kazmi K, Yusuf S, INTERHEART study investigators (2008) Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study. Lancet 372:224–233CrossRefPubMedGoogle Scholar
- Okamoto T, Yamori Y, Nagaoka A (1974) Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 34(35):143–153Google Scholar
- WHO-CARDIAC Study Group (1986) Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study protocol and manual of operations. WHO Collaborating Center on Primary Prevention of Cardiovascular Diseases, Izumo, Japan and Cardiovascular Diseases Unit, WHO, GenevaGoogle Scholar
- WHO-CARDIAC Study group (1990) Excerpts from the WHO CARDIAC Study Protocol. J Cardiovasc Pharmacol 16(Suppl 8):S75–S77Google Scholar
- Yamori Y (1984a) Development of the spontaneously hypertensive rat (SHR) and of various spontaneous rat models, and their implications. In: De Jong W (ed) Handbook of hypertension. Elsevier, Amsterdam, pp 224–239Google Scholar
- Yamori Y (1984b) The stroke-prone spontaneously hypertensive rat: contribution to risk factor analysis and prevention of hypertensive diseases. In: De Jong W (ed) Handbook of hypertension. Elsevier, Amsterdam, pp 240–255Google Scholar
- Yamori Y, Nara Y, Mizushima S, Mano M, Sawamura M, Kihara M, Horie R (1990) International cooperative study on the relationship between dietary factors and blood pressure: a report from the Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study. J Cardiovasc Pharmacol 16(Suppl 8):S43–S47CrossRefPubMedGoogle Scholar
- Yamori Y, Liu L, Ikeda K, Miura A, Mizushima S, Miki T, Nara Y, WHO-Cardiovascular Disease and Alimentary Comparison (CARDIAC) Study Group (2001) Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: results from the WHO-CARDIAC study. Hypertens Res 24(4):453–457CrossRefPubMedGoogle Scholar