Potential Anti-aging Role of Taurine via Proper Protein Folding: A Study from Taurine Transporter Knockout Mouse
Taurine is effective to several aging-related diseases. Taurine mediates a variety of biological actions, including osmoregulation and protein folding, which may contribute to its anti-aging role. Recent studies have proposed that the decline of protein homeostasis with advancing age leads to several aging-related disorders. Therefore, it is possible that the contribution of taurine to proper protein folding may be associated with the effectiveness against aging-related diseases. Meanwhile, Evidence accumulating from the studies with taurine transporter knockout (TauTKO) mouse has indicated that tissue taurine depletion led to aging-associated disorders in several tissues, including heart, skeletal muscle, liver, skin, and shortened the lifespan. Moreover, muscle taurine depletion causes ER stress to activate unfolded protein response. In conclusion, endogenous taurine acts as an anti-aging molecule via, in part, proper protein folding property.
KeywordsTaurine transporter knockout mouse Aging Lifespan Sarcopenia Osmolyte Protein folding Unfolded protein response
Taurine transporter knockout
This work was supported in part by JSPS KAKENHI Grant nos. 22790097, 80423119 and Uehara Memorial Foundation. This work was also supported by a grant from Taisho Pharmaceutical Co. Ltd.
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