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Taurine 9 pp 481-487 | Cite as

Potential Anti-aging Role of Taurine via Proper Protein Folding: A Study from Taurine Transporter Knockout Mouse

  • Takashi Ito
  • Natsuko Miyazaki
  • Stephen Schaffer
  • Junichi Azuma
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 803)

Abstract

Taurine is effective to several aging-related diseases. Taurine mediates a variety of biological actions, including osmoregulation and protein folding, which may contribute to its anti-aging role. Recent studies have proposed that the decline of protein homeostasis with advancing age leads to several aging-related disorders. Therefore, it is possible that the contribution of taurine to proper protein folding may be associated with the effectiveness against aging-related diseases. Meanwhile, Evidence accumulating from the studies with taurine transporter knockout (TauTKO) mouse has indicated that tissue taurine depletion led to aging-associated disorders in several tissues, including heart, skeletal muscle, liver, skin, and shortened the lifespan. Moreover, muscle taurine depletion causes ER stress to activate unfolded protein response. In conclusion, endogenous taurine acts as an anti-aging molecule via, in part, proper protein folding property.

Keywords

Taurine transporter knockout mouse Aging Lifespan Sarcopenia Osmolyte Protein folding Unfolded protein response 

Abbreviations

TauTKO

Taurine transporter knockout

WT

Wild type

Notes

Acknowledgements

This work was supported in part by JSPS KAKENHI Grant nos. 22790097, 80423119 and Uehara Memorial Foundation. This work was also supported by a grant from Taisho Pharmaceutical Co. Ltd.

References

  1. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479:232–236CrossRefPubMedCentralPubMedGoogle Scholar
  2. Burg MB, Ferraris JD (2008) Intracellular organic osmolytes: function and regulation. J Biol Chem 283:7309–7313CrossRefPubMedCentralPubMedGoogle Scholar
  3. El Idrissi A, Boukarrou L, Splavnyk K, Zavyalova E, Meehan EF, L’Amoreaux W (2009) Functional implication of taurine in aging. Adv Exp Med Biol 643:199–206CrossRefPubMedGoogle Scholar
  4. El Idrissi A, Shen CH, L’Amoreaux WJ (2013) Neuroprotective role of taurine during aging. Amino Acids 45:735–750CrossRefPubMedGoogle Scholar
  5. Fujii T, Ohkuri T, Onodera R, Ueda T (2007) Stable supply of large amounts of human Fab from the inclusion bodies in E. coli. J Biochem 141:699–707CrossRefPubMedGoogle Scholar
  6. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS et al (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392–395PubMedCentralPubMedGoogle Scholar
  7. Howard M, Fischer H, Roux J, Santos BC, Gullans SR, Yancey PH, Welch WJ (2003) Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function. J Biol Chem 278:35159–35167CrossRefPubMedGoogle Scholar
  8. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101–163PubMedGoogle Scholar
  9. Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M et al (2008) Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol 44:927–937CrossRefPubMedGoogle Scholar
  10. Ito T, Schaffer SW, Azuma J (2012) The potential usefulness of taurine on diabetes mellitus and its complications. Amino Acids 42:1529–1539CrossRefPubMedCentralPubMedGoogle Scholar
  11. Ito T, Yoshikawa N, Inui T, Miyazaki N, Schaffer S, Azuma J (2014a) Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice. PLoS One 9:e107409CrossRefPubMedCentralPubMedGoogle Scholar
  12. Ito T, Schaffer S, Azuma J (2014b) The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II. Amino Acids 46:111–119CrossRefPubMedGoogle Scholar
  13. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE (2004) Ink4a/Arf expression is a biomarker of aging. J Clin Invest 114:1299–1307CrossRefPubMedCentralPubMedGoogle Scholar
  14. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153:1194–1217CrossRefPubMedCentralPubMedGoogle Scholar
  15. Murakami S (2014) Taurine and atherosclerosis. Amino Acids 46:73–80CrossRefPubMedGoogle Scholar
  16. Nonaka H, Tsujino T, Watari Y, Emoto N, Yokoyama M (2001) Taurine prevents the decrease in expression and secretion of extracellular superoxide dismutase induced by homocysteine: amelioration of homocysteine-induced endoplasmic reticulum stress by taurine. Circulation 104:1165–1170CrossRefPubMedGoogle Scholar
  17. Pion PD, Kittleson MD, Rogers QR, Morris JG (1987) Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Science 237:764–768CrossRefPubMedGoogle Scholar
  18. Schaffer S, Takahashi K, Azuma J (2000) Role of osmoregulation in the actions of taurine. Amino Acids 19:527–546CrossRefPubMedGoogle Scholar
  19. Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F et al (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326:140–144CrossRefPubMedGoogle Scholar
  20. Sjovall J (1959) Dietary glycine and taurine on bile acid conjugation in man; bile acids and steroids 75. Proc Soc Exp Biol Med 100:676–678CrossRefPubMedGoogle Scholar
  21. Warskulat U, Flogel U, Jacoby C, Hartwig HG, Thewissen M, Merx MW, Molojavyi A, Heller-Stilb B, Schrader J, Haussinger D (2004) Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. FASEB J 18:577–579PubMedGoogle Scholar
  22. Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Monnighoff I, Buchczyk D, Donner M, Flogel U, Kappert G, Soboll S et al (2006) Chronic liver disease is triggered by taurine transporter knockout in the mouse. FASEB J 20:574–576PubMedGoogle Scholar
  23. Yancey PH (2005) Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. J Exp Biol 208:2819–2830CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Takashi Ito
    • 1
  • Natsuko Miyazaki
    • 1
  • Stephen Schaffer
    • 2
  • Junichi Azuma
    • 1
  1. 1.Department of Pharmacy, School of PharmacyHyogo University of Health SciencesKobeJapan
  2. 2.Department of Pharmacology, College of MedicineUniversity of South AlabamaMobileUSA

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