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Identifying Myocardial Mechanical Properties from MRI Using an Orthotropic Constitutive Model

  • Zhinuo J. WangEmail author
  • Vicky Y. Wang
  • Sue-Mun Huang
  • Justyna A. Niestrawska
  • Alistair A. Young
  • Martyn P. Nash
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8896)

Abstract

This paper presents a method to characterise the passive orthotropic and contractile properties of left ventricular (LV) myocardial tissue using MRI data of cardiac anatomy, structure and function. Personalised anatomical LV models were fitted to image data from four canine hearts. Diffusion tensor MRI data from the same hearts were parameterised using finite element fitting to provide fibre angle fields that represent longitudinal axes of the myocytes. Fitted fibre angle fields were combined with laminar-sheet orientation data extracted from the Auckland dog heart model and embedded into the customised LV anatomical models. A modified Holzapfel-Ogden orthotropic constitutive relation was parameterised using published data from ex vivo shear tests on myocardial tissue blocks. This parameterised constitutive model was scaled for each case in the present study by fitting the individualised LV models to end-diastolic image data. Contractile tension was then estimated by comparing LV model predictions to the end-systolic image data. Personalised models of this kind can be used to predict the 3D deformation and regional stress distributions throughout the LV wall during the entire cardiac cycle.

Keywords

Myocardial mechanical properties Orthotropic constitutive model Parameter estimation Canine heart Passive stiffness Active contraction Cardiac cycle 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Zhinuo J. Wang
    • 1
    Email author
  • Vicky Y. Wang
    • 1
  • Sue-Mun Huang
    • 1
  • Justyna A. Niestrawska
    • 2
  • Alistair A. Young
    • 1
    • 3
  • Martyn P. Nash
    • 1
    • 4
  1. 1.Auckland Bioengineering InstituteUniversity of AucklandAucklandNew Zealand
  2. 2.Institute of BiomechanicsGraz University of TechnologyGrazAustria
  3. 3.Department of Anatomy with RadiologyUniversity of AucklandAucklandNew Zealand
  4. 4.Department of Engineering ScienceUniversity of AucklandAucklandNew Zealand

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