Abstract
The nervous tissue is well protected by the bone, meningeal coverings and an immune system, from invasion by microbes. A breach in the protective barriers or a deficiency of the immune system may result in infection by various microorganisms such as bacteria, viruses, fungi and protozoa. This chapter begins with the list of terms used to describe infections in different neuroanatomical locations. The microorganisms causing CNS infection may be confined to certain geographic locations, affect specific neuroanatomical compartments and specific age groups. This chapter discusses some of the more common infections affecting the CNS worldwide with an emphasis on the role of brain biopsy and other newer microbiological tests in diagnosing these infectious diseases.
Keywords
Infection Microorganisms Meningitis Encephalitis AbscessReferences
- 1.Lin JJ, Harn HJ, Hsu YD, Tsao WL, Lee HS, Lee WH. Rapid diagnosis of tuberculous meningitis by polymerase chain reaction assay of cerebrospinal fluid. J Neurol. 1995;242(3):147–52.CrossRefPubMedGoogle Scholar
- 2.Shankar P, Manjunath N, Mohan KK, Prasad K, Behari M, Shriniwas, et al. Rapid diagnosis of tuberculous meningitis by polymerase chain reaction. Lancet. 1991;337(8732):5–7.CrossRefPubMedGoogle Scholar
- 3.Lynch T, Odel J, Fredericks DN, Louis ED, Forman S, Rotterdam H, et al. Polymerase chain reaction-based detection of Tropheryma whippelii in central nervous system Whipple’s disease. Ann Neurol. 1997;42(1):120–4.CrossRefPubMedGoogle Scholar
- 4.Tjensvoll AB, Gilhus NE. The post-poliomyelitis syndrome–a real complication. A poliomyelitis material from the Haukeland hospital. Tidsskr Nor Laegeforen. 1997;117(4):510–3.PubMedGoogle Scholar
- 5.Grehl O, Muller-Naendrup C, Jenni W. Postpolio syndrome: retrospective study in a former polio clinic. Praxis (Bern 1994). 1996;85(1–2):14–20.Google Scholar
- 6.Purtilo DT, Strobach RS, Okano M, Davis JR. Epstein-Barr virus-associated lymphoproliferative disorders. Lab Invest. 1992;67(1):5–23.PubMedGoogle Scholar
- 7.Farrington CP. Subacute sclerosing panencephalitis in England and Wales: transient effects and risk estimates. Stat Med. 1991;10(11):1733–44.CrossRefPubMedGoogle Scholar
- 8.Mandybur TI. The distribution of Alzheimer’s neurofibrillary tangles and gliosis in chronic subacute sclerosing panencephalitis. Acta Neuropathol. 1990;80(3):307–10.CrossRefPubMedGoogle Scholar
- 9.Centers for Disease Control (CDC). Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Council of State and Territorial Epidemiologists; AIDS Program, Center for Infectious Diseases. MMWR Morb Mortal Wkly Rep. 1987;36 Suppl 1:1S–5.Google Scholar
- 10.Pepin J, Milord F, Khonde AN, Niyonsenga T, Loko L, Mpia B, et al. Risk factors for encephalopathy and mortality during melarsoprol treatment of Trypanosoma brucei gambiense sleeping sickness. Trans R Soc Trop Med Hyg. 1995;89(1):92–7.CrossRefPubMedGoogle Scholar