Advertisement

Transplantation of Lymph Vessels

  • Michal KudlaEmail author

Abstract

The lymphatic system possesses very good regeneration capability, but it has its limitations. When the regeneration is not complete, within months or years there might develop decompensation of the lymphatic system leading to swelling of the tissue which contributes to worsening of the graft function. Investigating lymphatic vessels transplantation requires an appropriate model. The small intestine possesses a very well developed lymphatic system due to the enormous surface of mucosa and to continuous contact with infectious bowel content. Small bowel transplantation accompanied with reconstruction of lymphatic vessels appears to be the most appropriate model to study lymphatic vessels function in solid organ transplantation.

Keywords

Rat Lymphatic vessels Transplantation Small bowel 

References

  1. 1.
    Olszewski W (1973) On the pathomechanism of development of postsurgical lymphedema. Lymphology 6:35–51PubMedGoogle Scholar
  2. 2.
    Altorfer J, Clodius L (1976) Chronic experimental lymphedema of the extremities pathological changes. Experientia 32(7):823–824CrossRefPubMedGoogle Scholar
  3. 3.
    Goot B, Lillehei RC, Miller FA (1960) Mesenteric lymphatic regeneration after autografts of small bowel in dogs. Surgery 18:571–575Google Scholar
  4. 4.
    Kocandrle V, Houttuin E, Prohaska JV (1966) Regeneration of the lymphatic system after transplantation of the small intestine. Rozhl Chir 45:261–265PubMedGoogle Scholar
  5. 5.
    Schier F, Üner A, Waldschmidt J (1991) Microlymphography of spontaneous lymph vessel anastomosis in small bowel transplantation in the rat. J Pediatr Surg 26:1239–1242CrossRefPubMedGoogle Scholar
  6. 6.
    Schmid T, Koeroezsi G, Klima G, Margreiter R (1990) Lymphatic regeneration after small bowel transplantation. Transplant Proc 22:2060–2061PubMedGoogle Scholar
  7. 7.
    Olivier C, Rettori R, Olivier C, Camilleri JP (1972) Interruption of lymphatic vessels and its consequences in total homotransplantation of the small intestine and right side of colon in man. Lymphology 5:24–31PubMedGoogle Scholar
  8. 8.
    Stamford WP, Hardy MA (1974) Fatty acid absorption in jejunal autograft and allograft. Surgery 75:496–502PubMedGoogle Scholar
  9. 9.
    Rotman N, Michot F, Hay JM, Fagniez PL (1986) Lymphatic regeneration following intestinal transplantation in the pig. In: Deltz E, Thiede H, Hamelman H (eds) Small bowel transplantation: experimental and clinical fundamentals. Springer Verlag, Berlin, p 34CrossRefGoogle Scholar
  10. 10.
    Kalima TV (1970) Experimental lymphatic obstruction in the ileum. Ann Chir Gynaecol Fenn 59:187–201PubMedGoogle Scholar
  11. 11.
    Adams RH, Alitalo K (2007) Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 8:464–478CrossRefPubMedGoogle Scholar
  12. 12.
    Schraut WH, Lee KK, Sitrin M (1987) Recipient growth and nutritional status following transplantation of segmental small-bowel allografts. J Surg Res 43:1–9CrossRefPubMedGoogle Scholar
  13. 13.
    Kanokogi H, Ko S, Kanehiro H, Hisanaga M, Tatekawa Y, Kanamura T, Okayama J, Nakajima Y (2004) Immune responses of graft mesenteric lymph node in small bowel transplantation. J Surg Res 116:269–276CrossRefPubMedGoogle Scholar
  14. 14.
    Szymula von Richter TP, Baumeister RG, Hammer C (1996) Microsurgical reconstruction of the lymphatic and nerve system in small bowel transplantation: the rat model, first results. Transpl Int 9(Suppl 1):S286–289PubMedGoogle Scholar
  15. 15.
    Kellersman R, Zhong R, Kryochi H, Garcia B, Grant DR (2000) Reconstruction of the intestinal lymphatic drainage after small bowel transplantation. Transplantation 69:10–16CrossRefPubMedGoogle Scholar
  16. 16.
    Kudla M, Janotová D (2005) An experimental model of the lymphatic vessels transplantation. Rozhl Chir 84:422–425PubMedGoogle Scholar
  17. 17.
    Unthank JL, Bohlen HG (1988) Lymphatic pathways and role of valves in lymph propulsion from small intestine. Am J Physiol 254:389–398Google Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Transplantation SurgeryInstitute for Clinical and Experimental MedicinePragueCzech Republic

Personalised recommendations