THiMED: Time in Hierarchical Model Extraction and Design

  • Natasa Miskov-Zivanov
  • Peter Wei
  • Chang Sheng Clement Loh
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8859)


We describe our approach to modeling timing of cell signaling systems in which existing information about the system spans from detailed mechanistic knowledge to much coarser observations about cause and effect. The results for several models emphasize the fact that the selection of timing implementation can have both qualitative and quantitative effects on the model’s transient behavior and its steady state.


timing cell signaling stochastic model delay 


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Natasa Miskov-Zivanov
    • 1
    • 2
  • Peter Wei
    • 1
  • Chang Sheng Clement Loh
    • 1
  1. 1.Electrical and Computer Engineering DepartmentCarnegie Mellon UniversityUSA
  2. 2.Computer Science DepartmentCarnegie Mellon UniversityPittsburghUSA

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