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Partial Volume Correction of Cerebral Perfusion Estimates Obtained by Arterial Spin Labeling

  • K. Ambarki
  • J. Petr
  • A. Wåhlin
  • R. Wirestam
  • L. Zarrinkoob
  • J. Malm
  • A. Eklund
Part of the IFMBE Proceedings book series (IFMBE, volume 48)

Abstract

Arterial Spin labeling (ASL) is a fully noninvasive MRI method capable to quantify cerebral perfusion. However, gray (GM) and white matter (WM) ASL perfusions are difficult to assess separately due to limited spatial resolution increasing the partial volume effects (PVE). In the present study, ASL PVE correction was implemented based on a regression algorithm in 22 healthy young men. PVE corrected perfusion of GM and WM were compared to previous studies. PVE-corrected GM perfusion was in agreement with literature values. In general, WM perfusion was higher despite the use of PVE correction.

Keywords

MRI cerebral perfusion gray and white matter arterial spin labeling and healthy 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • K. Ambarki
    • 1
    • 2
  • J. Petr
    • 3
  • A. Wåhlin
    • 1
    • 4
  • R. Wirestam
    • 5
  • L. Zarrinkoob
    • 4
  • J. Malm
    • 4
  • A. Eklund
    • 1
    • 2
  1. 1.Department of Radiation SciencesUmeå UniversityUmeåSweden
  2. 2.Centre for Biomedical Engineering and PhysicsUmeå UniversityUmeåSweden
  3. 3.PET Center, Institute of Radiopharmaceutical Cancer ResearchHelmholtz-Zentrum Dresden-RossendorfDresdenGermany
  4. 4.Center for Functional Brain Imaging, Department of Clinical NeuroscienceUmeå UniversityUmeåSweden
  5. 5.Department of Medical Radiation PhysicsLund UniversityLundSweden

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