Abstract
Gene delivery by non-viral vectors is limited by cytotoxicity. In this study, we transferred plasmid DNA into stem cells by seeding cells on substrates with different physico-chemical properties. Gene entry was facilitated by the activation of integrins and cell motility on different material surface. The finding could be used to screen materials that promote cell migration and endocytosis.
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© 2015 Springer International Publishing Switzerland
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Huang, NC., Hsu, SH. (2015). The Transfectability and Cell Motility on Materials with Different Physico-chemical Properties. In: Su, FC., Wang, SH., Yeh, ML. (eds) 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol 47. Springer, Cham. https://doi.org/10.1007/978-3-319-12262-5_12
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DOI: https://doi.org/10.1007/978-3-319-12262-5_12
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-12261-8
Online ISBN: 978-3-319-12262-5
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