Cord Blood as a Treatment for Stroke

  • Alison E. WillingEmail author
  • E. A. Foran
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Over the last few decades, there has been an explosion in stem cell research. The investigation of umbilical cord blood (UCB) cells as a treatment for stroke is even more recent. Ease of collection and the ability to maintain their stem cell properties post-cryopreservation made these cells very attractive candidates for treatment development initially. UCB cells have many advantages including a wide variety of cell types present, including hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, lymphocytes, and monocytes, which enhances their ability to modulate multiple targets impacted by neurodegenerative processes. Although the precise mechanisms of action are still being researched, UCB cells have been shown to benefit functional recovery and also reduce infarct size post-stroke. They have also demonstrated an ability to provide these benefits when administered peripherally and within 24–48 h post-stroke, which immensely expands the current treatment window of 3–4 h for tissue plasminogen activator. This chapter highlights the current research with UCB cells in the development of a novel treatment for stroke and demonstrates the great therapeutic potential of these cells.


Glial Fibrillary Acidic Protein Brain Derive Neurotrophic Factor Umbilical Cord Blood Endothelial Progenitor Cell Oxygen Glucose Deprivation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Antibiotic antimycotic solution


Adult peripheral blood


Brain derived neurotrophic factor


Erythroid burst-forming units


Bone marrow


Center for disease control and prevention


Granulocyte-macrophage colony-forming units


Granulocyte/erythrocyte/macrophage/megakaryocyte colony-forming units


Common lymphoid progenitor


Central nervous system


Ciliary neurotrophic factor


Colony stimulating factor


Fractalkine receptor


Endothelial colony forming cells


Epidermal growth factor


Endothelial progenitor cells




Embryonic stem cell-derived mesenchymal stem cells


Exterior CD34-negative


Food and drug administration


Fibroblast growth factor


Granulocyte colony stimulating factor




Neural associated growth protein 43


Glial fibrillary acidic protein


Granulocyte and macrophage colony stimulating factor


Graft-versus-host disease


Human epidermal growth factor


Hepatic growth factor


Human leukocyte antigen


Hematopoeitic stem cells

hT cells

Jurkat T-cells




Intercellular adhesion molecule








Insulin-like growth factor


Insulin-like growth factor binding protein 2




Interior CD34-positive






Lactic acid dehydrogenase


Leukemia inhibitory factor


Leukocyte immunoglobulin-like receptor-8


Microtubule associated protein


Macrophage receptor with collagenous structure


Middle cerebral artery occlusion


Major histocompatibility complex


Mononuclear cell


Modified neurological severity score


Myeloid progenitor cells


Magnetic resonance imaging


Mesenchymal stem cells


Neuron-specific neural protein


Neurofilament heavy


Nerve growth factor


Natural killer


Nitric oxide


Neural stem cell


Neurotrophin 4/5


Octomer-binding transcription factor-4


Oxygen glucose deprivation


Phosphate buffered saline


Platelet-derived growth factor




Quantitative real time-polymerase chain reaction


Retinoic acid


Reactive oxygen species


Stem cell factor


Stromal cell-derived factor


Sex-determining region Y-box two


Stage specific embryonic antigen


Subventricular zone


Transforming growth factor


Tissue plasminogen activator




Tumor rejection antigen


III β-tubulin


Umbilical cord blood


Vascular adhesion molecule


Vascular endothelial growth factor


von Willebrand factor


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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Center for Excellence in Aging and Brain Repair, Department of Neurosurgery and Brain Repair, Morsani College of MedicineUniversity of South FloridaTampaUSA

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