Multifunctional Polymeric Nano-Carriers in Targeted Drug Delivery

  • Ashish Kumar Agrawal
  • Dileep Urimi
  • Sanyog JainEmail author
Part of the Advances in Delivery Science and Technology book series (ADST)


“The quest to achieve big shifted the focus of scientific community to small” seems to be quite strange to hear, but emergence of nanotechnology in the field of drug delivery made this wonder true. A meticulous look toward the evolution of nanotechnology clearly accentuates that the field has marched at a phenomenal pace with the emergence of nanoparticles like a “magic bullet.” Step-by-step engineering of the nanoparticles resulted in the development of multifunctional pharmaceutical nano-carriers combining multiple useful properties in single particle providing the theragnostic approach with improved safety and efficacy. This chapter elucidates in detail the concept of multifunctionality of polymeric nano-carriers for treatment of disease conditions particularly cancer. The chapter also covers the recent advances surrounding the multifunctionality of polymeric nanoparticles for improved therapeutic outcomes.


Multifunctionality Nanoparticles Ligands Targeting Imaging 



Anthracene-9, 10-dipropionic acid, disodium salt




Blood–brain barrier


Bone morphogenetic protein






Confocal laser scanning microscopy


Central nervous system


Cyclo oxygenase


Deoxy nucleic acid




Ethyl cellulose


Extracellular matrices


Epidermal growth factor


Expressing green fluorescent protein


Epidermal growth factor receptor


Enhanced permeability and retention effect


Folic acid


Food and Drug Administration


Fibroblast growth factor


Fluorescein isothiocyanate


Glycyrrhizinic acid






Hepatitis B virus


Hepatitis C virus


Human epidermal growth factor receptor 2




Monoclonal antibodies


Methyl cellulose


Multidrug resistance


Multifunctional envelope-type nano-device


multifunctional magneto-polymeric nanohybrids


Myristoylated polyarginine peptides


Magnetic Resonance Imaging


messenger RNA


Nanoparticles-in-microsphere oral system


Near-infrared fluorescent dye




Polyacrylic cid


Poly (β-benzyl l-aspartate)




Plasmid deoxyribonucleic acid


Polyethylene glycol






Poly lactic acid


(poly(lactic-co-glycolic) acid)


Poly (l-lysine)








Quantum dots


Rhodamine B isothiocyanate


Reticuloendothelial system


Arginine–glycine–aspartic acid


Ribo nucleic acid


Single chain prostate stem cell antigen antibodies


Single-chain fragment variables


Small interfering RNA


Single-photon emission computed tomography


Superparamagnetic iron oxide nanoparticles


Transferrin receptors


d-α-tocopheryl polyethylene glycol succinate


Vascular endothelial growth factor


Wheat germ agglutinin


γ-polyglutamic acid


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Copyright information

© Controlled Release Society 2015

Authors and Affiliations

  • Ashish Kumar Agrawal
    • 1
  • Dileep Urimi
    • 1
  • Sanyog Jain
    • 1
    Email author
  1. 1.Centre for Pharmaceutical Nanotechnology, Department of PharmaceuticsNational Institute of Pharmaceutical Education and Research (NIPER)MohaliIndia

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