The Near Future of Endoscopic Screening in IBD

  • Ralf Kiesslich
  • Johannes Wilhelm Rey
  • Arthur Hoffman
Chapter
First Online:

Abstract

Patients with long-standing extensive chronic inflammatory bowel disease (IBD) have an increased risk of developing intraepithelial neoplasia and colitis-associated cancer (CAC) compared to the average risk population. In 2003, the first randomized, controlled trial was published evaluating lesions in the colon according to a modified Pit-Pattern classification after pan-chromoendoscopy with methylene blue (0.1 %). Chromoendoscopy enabled unmasking dysplastic lesions and clarifying the borders between neoplastic and normal tissue. This has led to the “smart biopsy” concept, where more targeted biopsies become possible after enhanced endoscopy (chromoendoscopy). In addition, confocal laser endomicroscopy (CLE) has revealed in vivo tissue changes in vessel, connective tissue and cellular-subcellular structures.

Keywords

Inflammatory bowel disease (IBD) Intraepithelial neoplasia Colitis associated cancer (CAC) Confocal laser endomicroscopy (CLE) Chromoendoscopy Functional imaging 
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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Ralf Kiesslich
    • 1
  • Johannes Wilhelm Rey
    • 2
  • Arthur Hoffman
    • 3
  1. 1.Medical DepartmentSt. Marienkrankenhaus FrankfurtFrankfurtGermany
  2. 2.Department for Internal MedicineMedizinische Klinik, St. MarienkrankenhausFrankfurtGermany
  3. 3.Department for Internal Medicine, Gastroenterology and OncologySt. MarienkrankenhausFrankfurtGermany

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