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Acinic Cell Carcinoma

  • Joaquín J. García
Chapter

Abstract

Acinic cell carcinoma affects children and adults and presents at a mean age of approximately 50 years. Women are involved slightly more than men. The majority of cases involve major salivary glands, presenting as single or multiple masses. Most cases of acinic cell carcinoma behave as low- to intermediate-grade malignancies; however, a subset of cases with high-grade transformation (necrosis, elevated mitotic activity, and cytomorphologic atypia) are predisposed to recurrence, lymph node involvement, and distant metastasis. Acinic cell carcinoma may be well-circumscribed or infiltrative, comprised of multiple cell types (e.g., acinar, ductal), and exhibit a variety of architectural patterns (follicular, solid, and microcystic) (Figs. 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 6.10, 6.11, 6.12, 6.13, 6.14, 6.15, 6.16, 6.17, 6.18, 6.19, 6.20, 6.21, 6.22, 6.23, 6.24, 6.25, 6.26, 6.27, 6.28, 6.29, 6.30, 6.31, 6.32, 6.33, 6.34, 6.35, 6.36, 6.37, 6.38, 6.39, 6.40, 6.41, 6.42 and 6.43).

Keywords

Acinic cell adenocarcinoma Acinar cell carcinoma Acinic cell tumor 

Suggested Reading

  1. Ali SZ. Acinic-cell carcinoma, papillary-cystic variant: a diagnostic dilemma in salivary gland aspiration. Diagn Cytopathol. 2002;27(4):244–50.CrossRefGoogle Scholar
  2. Bishop JA, Yonescu R, Batista D, Eisele DW, Westra WH. Most nonparotid “acinic cell carcinomas” represent mammary analog secretory carcinomas. Am J Surg Pathol. 2013;37(7):1053–7.CrossRefGoogle Scholar
  3. Chiosea SI, Griffith C, Assaad A, Seethala RR. The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma. Am J Surg Pathol. 2012;36(3):343–50.CrossRefGoogle Scholar
  4. Gomez DR, Katabi N, Zhung J, Wolden SL, Zelefsky MJ, Kraus DH, et al. Clinical and pathologic prognostic features in acinic cell carcinoma of the parotid gland. Cancer. 2009;115(10):2128–37.CrossRefGoogle Scholar
  5. Ihrler S, Blasenbreu-Vogt S, Sendelhofert A, Lang S, Zietz C, Lohrs U. Differential diagnosis of salivary acinic cell carcinoma and adenocarcinoma (NOS). A comparison of (immuno-) histochemical markers. Pathol Res Pract. 2002;198(12):777–83.PubMedGoogle Scholar
  6. Lei Y, Chiosea SI. Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head Neck Pathol. 2012;6(2):166–70.CrossRefGoogle Scholar
  7. Lin WN, Huang HC, Wu CC, Liao CT, Chen IH, Kan CJ, et al. Analysis of acinic cell carcinoma of the parotid gland: 15 years experience. Acta Otolaryngol. 2010;130(12):1406–10.CrossRefGoogle Scholar
  8. Piana S, Cavazza A, Pedroni C, Scotti R, Serra L, Gardini G. Dedifferentiated acinic cell carcinoma of the parotid gland with myoepithelial features. Arch Pathol Lab Med. 2002;126(9):1104–5.PubMedGoogle Scholar
  9. Roy S, Dhingra KK, Gupta P, Khurana N, Gupta B, Meher R. Acinic cell carcinoma with extensive neuroendocrine differentiation: a diagnostic challenge. Head Neck Pathol. 2009;3(2):163–8.CrossRefGoogle Scholar
  10. Skalova A, Sima R, Vanecek T, Muller S, Korabecna M, Nemcova J, et al. Acinic cell carcinoma with high-grade transformation: a report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/neu genes. Am J Surg Pathol. 2009;33(8):1137–45.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

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