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Secretory Carcinoma

  • Joaquín J. García
Chapter

Abstract

Secretory carcinoma affects children and adults and presents at a mean age of approximately 45 years. Women and men are involved with similar frequency. The majority of cases involve the parotid gland, presenting as single or multiple masses. Most cases of secretory carcinoma behave as low- to intermediate-grade malignancies; however, a subset of cases with high-grade transformation (necrosis, elevated mitotic activity, and cytomorphologic atypia) are predisposed to recurrence, lymph node involvement, and distant metastasis. Secretory carcinoma may be well-circumscribed or infiltrative, comprised of multiple cell types, and exhibit a variety of architectural patterns (solid, follicular, papillary, and microcystic) (Figs. 26.1, 26.2, 26.3, 26.4, 26.5, 26.6, 26.7, 26.8, 26.9, 26.10, 26.11, 26.12, 26.13, 26.14, 26.15, 26.16, 26.17, 26.18, 26.19, 26.20, 26.21, 26.22, 26.23, 26.24, 26.25, 26.26, 26.27, 26.28, 26.29 and 26.30).

Keywords

Mammary analogue secretory carcinoma 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

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