Pleomorphic Adenoma, Carcinoma Ex

  • Joaquín J. García


Carcinoma ex pleomorphic adenoma is the malignant counterpart of pleomorphic adenoma. Carcinoma ex pleomorphic adenoma affects primarily adults and presents at a mean age of approximately 60 years. Women are involved more than men. The majority of cases involve the parotid gland, presenting as single or multiple masses. Carcinoma ex pleomorphic adenoma may be well-circumscribed (noninvasive) or infiltrative (invasive), comprised of multiple cell types (ductal, myoepithelial, and chondromyxoid stromal), and exhibit a variety of architectural patterns (solid, cystic, and cartilaginous) (Figs. 23.1, 23.2, 23.3, 23.4, 23.5, 23.6, 23.7, 23.8, 23.9, 23.10, 23.11, 23.12, 23.13, 23.14, 23.15, 23.16, 23.17, 23.18, 23.19, 23.20, 23.21, 23.22, 23.23, 23.24, 23.25, 23.26, 23.27, 23.28, 23.29, 23.30, 23.31, 23.32, 23.33, 23.34, 23.35, 23.36, 23.37, 23.38, 23.39 and 23.40).


Carcinoma ex mixed tumor Malignant mixed tumor Carcinoma arising in a pleomorphic adenoma 

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© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

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