Myoepithelial Carcinoma

  • Joaquín J. García


Myoepithelial carcinoma is the malignant counterpart of myoepithelioma. Myoepithelial carcinoma affects children and adults. Women and men are involved with similar frequency. The majority of cases involve major salivary glands, presenting as single or multiple masses. Most cases of myoepithelial carcinoma behave as intermediate- to high-grade malignancies. Myoepithelial carcinoma may be well-circumscribed or infiltrative, comprised almost exclusively of one cell type (myoepithelial), and exhibit a variety of architectural patterns (nests, cords, and trabeculae) (Figs. 19.1, 19.2, 19.3, 19.4, 19.5, 19.6, 19.7, 19.8, 19.9, 19.10, 19.11, 19.12, 19.13, 19.14, 19.15, 19.16, 19.17, 19.18, 19.19, 19.20, 19.21 and 19.22).


Malignant myoepithelioma 

Suggested Reading

  1. Bastaki JM, Purgina BM, Dacic S, Seethala RR. Secretory myoepithelial carcinoma: a histologic and molecular survey and a proposed nomenclature for mucin producing signet ring tumors. Head Neck Pathol. 2014;8:250–60.CrossRefGoogle Scholar
  2. Chhieng DC, Paulino AF. Cytology of myoepithelial carcinoma of the salivary gland. Cancer. 2002;96(1):32–6.CrossRefGoogle Scholar
  3. Di Palma S, Guzzo M. Malignant myoepithelioma of salivary glands: clinicopathological features of ten cases. Virchows Arch A Pathol Anat Histopathol. 1993;423:389–96.CrossRefGoogle Scholar
  4. Gnepp DR. Malignant mixed tumors of the salivary glands: a review. Pathol Annu. 1993;28:279–328.PubMedGoogle Scholar
  5. Kong M, Drill EN, Morris L, West L, Klimstra D, Gonen M, et al. Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. Am J Surg Pathol. 2015;39:931–8.CrossRefGoogle Scholar
  6. Savera AT, Sloman A, Huvos AG, Klimstra DS. Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 25 patients. Am J Surg Pathol. 2000;24(6):761–74.CrossRefGoogle Scholar
  7. Skalova A, Weinreb I, Hyrcza M, Simpson RH, Laco J, Agaimy A, et al. Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol. 2015;39:338–48.CrossRefGoogle Scholar
  8. Su YX, Roberts DB, Hanna EY, El-Naggar A, Saylam G, Frank SJ, et al. Risk factors and prognosis for myoepithelial carcinoma of the major salivary glands. Ann Surg Oncol. 2015;22:3701–7.CrossRefGoogle Scholar
  9. Yu G, Ma D, Sun K, Li T, Zhang Y. Myoepithelial carcinoma of the salivary glands: behavior and management. Chin Med J. 2003;116(2):163–5.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

Personalised recommendations