Advertisement

Myoepithelioma

  • Joaquín J. García
Chapter

Abstract

Myoepithelioma is the benign counterpart of myoepithelial carcinoma. Myoepithelioma affects children and adults and presents at a mean age of approximately 45 years. Women and men are involved with similar frequency. The majority of cases involve major salivary glands, presenting as single or multiple masses. Myoepithelioma may be well-circumscribed or multinodular, comprised almost exclusively of one cell type (myoepithelial), and exhibit a variety of architectural patterns (nests, cords, and trabeculae) (Figs. 18.1, 18.2, 18.3, 18.4, 18.5, 18.6, 18.7, 18.8, 18.9, 18.10, 18.11, 18.12, 18.13, 18.14, 18.15, 18.16, 18.17, 18.18, 18.19, 18.20, 18.21, 18.22 and 18.23).

Keywords

Myoepithelial adenoma Benign myoepithelial tumor 

Suggested Reading

  1. Alos L, Cardesa A, Bombi JA, Mallofre C, Cuchi A, Traserra J. Myoepithelial tumors of salivary glands: a clinicopathologic, immunohistochemical, ultrastructural, and flow-cytometric study. Semin Diagn Pathol. 1996;13:138–47.PubMedGoogle Scholar
  2. Barnes L, Appel BN, Perez H, El-Attar AM. Myoepithelioma of the head and neck: case report and review. J Surg Oncol. 1985;28:21–8.CrossRefGoogle Scholar
  3. Dardick I, Cavell S, Boivin M, Hoppe D, Parks WR, Stinson J, et al. Salivary gland myoepithelioma variants. Histological, ultrastructural, and immunocytological features. Virchows Arch A Pathol Anat Histopathol. 1989a;416(1):25–42.CrossRefGoogle Scholar
  4. Dardick I, Thomas MJ, van Nostrand AW. Myoepithelioma—new concepts of histology and classification: a light and electron microscopic study. Ultrastruct Pathol. 1989b;13(2–3):187–224.CrossRefGoogle Scholar
  5. Dardick I, Ostrynski VL, Ekem JK, Leung R, Burford-Mason AP. Immunohistochemical and ultrastructural correlates of muscle-actin expression in pleomorphic adenomas and myoepitheliomas based on comparison of formalin and methanol fixation. Virchows Arch A Pathol Anat Histopathol. 1992;421:95–104.CrossRefGoogle Scholar
  6. Di Palma S, Guzzo M. Malignant myoepithelioma of salivary glands: clinicopathological features of ten cases. Virchows Arch A Pathol Anat Histopathol. 1993;423(5):389–96.CrossRefGoogle Scholar
  7. DiPalma S, Alasio L, Pilotti S. Fine needle aspiration (FNA) appearances of malignant myoepithelioma of the parotid gland. Cytopathology. 1996;7(5):357–65.CrossRefGoogle Scholar
  8. Ellis GL, Auclair PL. Tumors of the salivary glands. In: AFIP atlas of tumor pathology, 4th series. Silver Spring: ARP Press; 2008. p. 495–7.Google Scholar
  9. Gnepp DR. Mucinous myoepithelioma, a recently described new myoepithelioma variant. Head Neck Pathol. 2013;7(Suppl 1):S85–9.CrossRefGoogle Scholar
  10. Hungermann D, Roeser K, Buerger H, Jakel T, Loning T, Herbst H. Relative paucity of gross genetic alterations in myoepitheliomas and myoepithelial carcinomas of salivary glands. J Pathol. 2002;198(4):487–94.CrossRefGoogle Scholar
  11. Laikui L, Hongwei L, Hongbing J, Zhixiu H. Epithelial salivary gland tumors of children and adolescents in West China population: a clinicopathologic study of 79 cases. J Oral Pathol Med. 2008;37:201–5.CrossRefGoogle Scholar
  12. Leifer C, Miller AS, Putong PB, Harwick RD. Myoepithelioma of the parotid gland. Arch Pathol. 1974;98:312–9.PubMedGoogle Scholar
  13. Nagao T, Sugano I, Ishida Y, Tajima Y, Matsuzaki O, Konno A, et al. Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. Cancer. 1998;83(7):1292–9.CrossRefGoogle Scholar
  14. Sciubba JJ, Brannon RB. Myoepithelioma of salivary glands: report of 23 cases. Cancer. 1982;49(3):562–72.CrossRefGoogle Scholar
  15. Simpson RH, Jones H, Beasley P. Benign myoepithelioma of the salivary glands: a true entity? Histopathology. 1995;27:1–9.CrossRefGoogle Scholar
  16. Turgut S, Cekic A, Ergul G, Aksoy F, Seckin S, Ozdem C. Myoepithelioma of the parotid gland: a report of two cases. Ear Nose Throat J. 2001;80:155–8.PubMedGoogle Scholar
  17. Yaman H, Gerek M, Tosun F, Deveci S, Kilic E, Arslan HH. Myoepithelioma of the parotid gland in a child: a case report. J Pediatr Surg. 2010;45:E5–7.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joaquín J. García
    • 1
  1. 1.Mayo Clinic School of Medicine, Department of Laboratory Medicine & PathologyMayo Clinic RochesterRochesterUSA

Personalised recommendations