Advertisement

A Simulation for Proportional Biological Operational Mu-Circuit

  • Dechang Xu
  • Zhipeng Cai
  • Ke Liu
  • Xiangmiao Zeng
  • Yujing Ouyang
  • Cuihong Dai
  • Aiju Hou
  • Dayou Cheng
  • Jianzhong Li
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8492)

Abstract

To quantitatively control the expression of target gene is challenging but highly desired in practice. We design a device-Biological Proportional Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that we can control input-output proportionly by manipulating the RBS of hrpR, hrpS, tetR and output gene.

Keywords

Simulation Proportional regulation Modeling 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mjolsness, E., Sharp, D.H., Reinitz, J.: A connectionist model of development. J. Theor. Biol. 152, 429–453 (1991)CrossRefGoogle Scholar
  2. 2.
    McAdams, H.H., Shapiro, L.: Circuit simulation of genetic networks. Science 269, 650–656 (1995)CrossRefGoogle Scholar
  3. 3.
    Reinitz, J., Sharp, D.H.: Gene circuits and their uses. In: Collado-Vides, J., Magasanik, B., Smith, T.F. (eds.) Integrative Approaches to Molecular Biology, pp. 253–272. MIT Press, Cambridge (1996)Google Scholar
  4. 4.
    Sharp, D.H., Reinitz, J.: Prediction of mutant expression patterns using gene circuits. BioSystems 47, 79–90 (1998)CrossRefGoogle Scholar
  5. 5.
    Weiss, R., Knight, T.F.: Engineered Communications for Microbial Robotics. In: Condon, A., Rozenberg, G. (eds.) DNA 2000. LNCS, vol. 2054, pp. 1–16. Springer, Heidelberg (2001)CrossRefGoogle Scholar
  6. 6.
    Hasty, J., McMillen, D., Collins, J.J.: Engineered gene circuits. Nature 420, 224–230 (2002)CrossRefGoogle Scholar
  7. 7.
    Rackham, O., Chin, J.W.: A network of orthogonal ribosome∙mRNA pairs. Nature Chemical Biology 1, 159–166 (2005)CrossRefGoogle Scholar
  8. 8.
    Schmidt, H., Jirstrand, M.: Systems Biology Toolbox for MATLAB: a computa-tional platform for research in systems biology. Bioinformatics 22, 514–515 (2006)CrossRefGoogle Scholar
  9. 9.
    de Jong, H.: Modeling and Simulation of Genetic Regulatory Systems: A Li-terature Review. Journal of Computational Biology 9(1), 67–103 (2002)CrossRefGoogle Scholar
  10. 10.
    Kayali, G., Kandeil, A., El-Shesheny, R., Kayed, A., Gomaa, M.M., Maatouq, A., Shehata, M.M., Moatasim, Y., Bagato, O., Cai, Z., Rubrum, A., Kutkat, M., McKen-zie, P., Webster, R., Webby, R., Ali, M.: Active Surveillance for Avian Influenza Virus, Egypt, 2010 - 2012. Emerging Infectious Diseases Journal 20(4) (2014)Google Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Dechang Xu
    • 1
  • Zhipeng Cai
    • 2
  • Ke Liu
    • 1
  • Xiangmiao Zeng
    • 1
  • Yujing Ouyang
    • 1
  • Cuihong Dai
    • 1
  • Aiju Hou
    • 1
  • Dayou Cheng
    • 1
  • Jianzhong Li
    • 1
  1. 1.Harbin Institute of TechnologyHarbinChina
  2. 2.Georgia State UniversityAtlantaUSA

Personalised recommendations