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Computational Modeling of the Main Signaling Pathways Involved in Mast Cell Activation

  • Anna Niarakis
  • Yacine Bounab
  • Luca Grieco
  • Romain Roncagalli
  • Anne-Marie Hesse
  • Jérôme Garin
  • Bernard Malissen
  • Marc Daëron
  • Denis ThieffryEmail author
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 382)

Abstract

A global and rigorous understanding of the signaling pathways and cross-regulatory processes involved in mast cell activation requires the integration of published information with novel functional datasets into a comprehensive computational model. Based on an exhaustive curation of the existing literature and using the software CellDesigner, we have built and annotated a comprehensive molecular map for the FcεRI signaling network. This map can be used to visualize and interpret high-throughput expression data. Furthermore, leaning on this map and using the logical modeling software GINsim, we have derived a qualitative dynamical model, which recapitulates the most salient features of mast cell activation. The resulting logical model can be used to explore the dynamical properties of the system and its responses to different stimuli, in normal or mutant conditions.

Keywords

Mast Cell Lipid Raft Mast Cell Activation Logical Rule System Biology Graphical Notation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This project was supported by the ANR through the MI2 project iSa and by the proteomics ProFI infrastructure, as well as by the French excellence initiatives MemoLife LabEx and PSL* IdEx.

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Anna Niarakis
    • 1
    • 2
    • 3
  • Yacine Bounab
    • 4
    • 6
  • Luca Grieco
    • 1
    • 2
    • 3
  • Romain Roncagalli
    • 5
    • 7
    • 8
  • Anne-Marie Hesse
    • 9
    • 10
    • 11
  • Jérôme Garin
    • 9
    • 10
    • 11
  • Bernard Malissen
    • 5
    • 7
    • 8
  • Marc Daëron
    • 13
    • 12
  • Denis Thieffry
    • 1
    • 2
    • 3
    Email author
  1. 1.Institut de Biologie de l’ENS (IBENS)Ecole Normale SupérieureParisFrance
  2. 2.INSERM, U1024ParisFrance
  3. 3.CNRS, UMR 8197ParisFrance
  4. 4.Unité d’Allergologie Moléculaire et Cellulaire, Département d’ImmunologieInstitut PasteurParisFrance
  5. 5.Centre d’Immunologie de Marseille-Luminy (CIML)Université Aix MarseilleMarseilleFrance
  6. 6.INSERM, UMS20ParisFrance
  7. 7.INSERM, U1104MarseilleFrance
  8. 8.CNRS, UMR7280MarseilleFrance
  9. 9.Laboratoire de Biologie à Grande EchelleCEA, IRTSVGrenobleFrance
  10. 10.INSERM, U1038GrenobleFrance
  11. 11.Laboratoire de Biologie à Grande EchelleUniversité de Grenoble Alpes, iRTSVGrenobleFrance
  12. 12.Institut PasteurParisFrance
  13. 13.Inserm, U1104Centre d’Immunologie de Marseille-LuminyMarseilleFrance

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