Mammographic Density and Breast Cancer Characteristics
The aim of this research is to investigate, in a screening population, the relationship between mammographic density and tumour characteristics including size, invasiveness and mammographic features. Mammograms of 105 women with screen detected breast cancer were analysed; 111 lesions were identified. Volumetric density measurements were obtained using QuantaTM and VolparaTM. Histological information was extracted from the screening database and radiological features were assessed by two expert breast radiologists. Statistical analysis was performed using Mann-Whitney U test and Spearman’s rank order correlation. The median percentage density by VolparaTM of women with invasive cancers was significantly higher than those with DCIS (6.5 vs 5.0, p =0.046). Similar results were replicated in the QuantraTM measurements, however the results were not statistically significant (17 vs 16, p = 0.19). Further analysis showed a significant positive association between whole tumour size and volumetric density for invasive lesions. Architectural distortion was the only mammographic feature associated with a significant difference in percentage density.
KeywordsScreening mammogram cancer volumetric breast density invasive DCIS distortion
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