S1P Control of Endothelial Integrity

  • Yuquan Xiong
  • Timothy HlaEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 378)


Sphingosine 1-phosphate (S1P), a lipid mediator produced by sphingolipid metabolism, promotes endothelial cell spreading, vascular maturation/stabilization, and barrier function. S1P is present at high concentrations in the circulatory system, whereas in tissues its levels are low. This so-called vascular S1P gradient is essential for S1P to regulate much physiological and pathophysiological progress such as the modulation of vascular permeability. Cellular sources of S1P in blood has only recently begun to be identified. In this review, we summarize the current understanding of S1P in regulating vascular integrity. In particular, we discuss the recent discovery of the endothelium-protective functions of HDL-bound S1P which is chaperoned by apolipoprotein M.


Acute Lung Injury Myosin Light Chain Kinase Dengue Hemorrhagic Fever Myosin Light Chain Phosphorylation Vascular Barrier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Adherens junctions


Acute kidney injury


Acute lung injury


Apolipoprotein M


Bronchoalveolar lavage


Endothelial cells


Endothelial nitric oxide synthase


Guanine nucleotide exchange factors


Gap junctions


High-density lipoprotein


Human umbilical vein endothelial cells




Junctional adhesion molecules


Low-density lipoprotein


Lysophospholipid phosphatase 3






Myosin light chain


Myosin light chain kinase


Platelet-activating factor




Platelet-endothelial cell adhesion molecule-1


Red blood cells


Sphingosine 1-phosphate




Spinster 2


S1P phosphatases


Transmonolayer electrical resistance


Tight junctions


Vascular endothelial cadherin


Very low-density lipoprotein


Zona occludens proteins


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Center for Vascular Biology, Department of Pathology and Laboratory MedicineWeill Cornell Medical College, Cornell UniversityNew YorkUSA

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