Making Ribosomes: Pre-rRNA Transcription and Processing

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Abstract

Ribosomes are essential, intricate cellular machines that translate mRNA into protein in all cells. The process of building a ribosome is highly complex. The ribosomal RNA (rRNA) has to be properly synthesized, processed, and assembled with ribosomal proteins in the cell nucleolus. Studies carried out in yeast have significantly increased our understanding of the mechanisms driving ribosome assembly in eukaryotes. This chapter will briefly review ribosome assembly in Saccharomyces cerevisiae and discuss what is known about ribosome assembly in other yeast species.

Keywords

Yeast Species Assembly Factor Ribosome Biogenesis rDNA Repeat Pathogenic Yeast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Department of GeneticsYale University School of MedicineNew HavenUSA
  2. 2.Department of Molecular Biophysics and BiochemistryYale University School of MedicineNew HavenUSA
  3. 3.Department of Therapeutic RadiologyYale University School of MedicineNew HavenUSA

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