First Clinical Experience with BMD Assessment in Vertebrae Using Dual-Energy CT

  • Stefan Wesarg
  • Julian Wichmann
  • Christian Booz
  • Marius Erdt
  • Konstantinos Kafchitsas
  • M. Fawad Khan
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8361)


Dual-energy CT (DECT) can be performed with state-of-the-art dual-source CT (DSCT) scanners and allows for assessing bone mineral density (BMD). In this work, we present first clinical experience with in vivo BMD assessment of vertebrae based on DECT data which has been acquired with a state-of-the-art DSCT scanner in the clinical routine. In contrast to previous work where we did in vitro tests of our method, we apply it her for the first time to in vivo data and prove the feasibility of our technique in a clinical setting. For \(25\) patients, DXA as well as DECT data have been acquired and BMD of vertebrae was assessed. Advantages of DECT are its 3D capabilities allowing to compute the spatial BMD distribution and to focus the examination on the trabecular bone. Correlation between both imaging techniques regarding the averaged BMD values per vertebra are only moderate.


Bone mineral density Dual-energy CT Osteoporosis 


  1. 1.
    Adams, J.E.: Quantitative computed tomography. Eur. J. Radiol. 71(3), 415–424 (2009)CrossRefGoogle Scholar
  2. 2.
    Blake, G.M., Fogelman, I.: The clinical role of dual energy X-ray absorptiometry. Eur. J. Radiol. 71(3), 406–414 (2009)CrossRefGoogle Scholar
  3. 3.
    Engelke, K., Adams, J.E., Armbrecht, G., Augat, P., Bogado, C.E., Bouxsein, M.L., Felsenberg, D., Ito, M., Prevrhal, S., Hans, D.B., Lewiecki, E.M.: Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD official positions. J. Clin. Densitometry 11(1), 123–162 (2008)CrossRefGoogle Scholar
  4. 4.
    Erdt, M., Kirschner, M., Wesarg, S.: Simultaneous segmentation and correspondence establishment for statistical shape models. In: Magnenat-Thalmann, N. (ed.) 3DPH 2009. LNCS, vol. 5903, pp. 25–35. Springer, Heidelberg (2009)Google Scholar
  5. 5.
    Flohr, T.G., McCollough, C.H., Bruder, H., Petersilka, M., Gruber, K., Süß, C., Grasruck, M., Stierstorfer, K., Krauss, B., Raupach, R., Primak, A.N., Küttner, A., Achenbach, S., Becker, C., Kopp, A., Ohnesorge, B.M.: First performance evaluation of a dual-source CT (DSCT) system. Eur. Radiol. 16(2), 256–268 (2006)CrossRefGoogle Scholar
  6. 6.
    Genant, H.K., Boyd, D.: Quantitative bone mineral analysis using dual energy computed tomography. Invest. Radiol. 12(6), 545–551 (1977)CrossRefGoogle Scholar
  7. 7.
    Nickoloff, E.L., Feldman, F., Atherton, J.V.: Bone mineral assessment: new dual-energy CT approach. Radiology 168(1), 223–228 (1988)Google Scholar
  8. 8.
    Singer, A.: Osteoporosis diagnosis and screening. Clin. Cornerstone 8(1), 9–18 (2006)CrossRefGoogle Scholar
  9. 9.
    van Kuijk, C., Grashuis, J.L., Steenbeek, J.C., Schütte, H.E., Trouerbach, W.T.: Evaluation of postprocessing dual-energy methods in quantitative computed tomography. Part 2. Practical aspects. Invest. Radiol. 25(8), 882–889 (1990)CrossRefGoogle Scholar
  10. 10.
    Wesarg, S., Kirschner, M., Becker, M., Erdt, M., Kafchitsas, K., Khan, M.F.: Dualenergy CT-based assessment of the trabecular bone in vertebrae. Meth. Inf. Med. 51(5), 398–405 (2012)CrossRefGoogle Scholar
  11. 11.
    WHO - World Health Organization: WHO Scientific Group on the Assessment of Osteoporosis at Primary Health Care Level (2007), summary Meeting Report Brussels, Belgium, 5–7 May 2004Google Scholar
  12. 12.
    Yoganandan, N., Pintar, F.A., Stemper, B.D., Baisden, J.L., Aktay, R., Shender, B.S., Paskoff, G., Laud, P.: Trabecular bone density of male human cervical and lumbar vertebrae. Bone 39(2), 336–344 (2006)CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Stefan Wesarg
    • 1
  • Julian Wichmann
    • 2
  • Christian Booz
    • 2
  • Marius Erdt
    • 3
  • Konstantinos Kafchitsas
    • 4
  • M. Fawad Khan
    • 2
  1. 1.Fraunhofer Institute for Computer Graphics ResearchDarmstadtGermany
  2. 2.Institute for Diagnostic and Interventional RadiologyGoethe UniversityFrankfurt am MainGermany
  3. 3.Fraunhofer IDM@NTUSingaporeSingapore
  4. 4.Clinic and Polyclinic for Orthopedics and Orthopedic SurgeryUniversitätsmedizin MainzMainzGermany

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