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Decoding Coalescent Hidden Markov Models in Linear Time

  • Kelley Harris
  • Sara Sheehan
  • John A. Kamm
  • Yun S. Song
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8394)

Abstract

In many areas of computational biology, hidden Markov models (HMMs) have been used to model local genomic features. In particular, coalescent HMMs have been used to infer ancient population sizes, migration rates, divergence times, and other parameters such as mutation and recombination rates. As more loci, sequences, and hidden states are added to the model, however, the runtime of coalescent HMMs can quickly become prohibitive. Here we present a new algorithm for reducing the runtime of coalescent HMMs from quadratic in the number of hidden time states to linear, without making any additional approximations. Our algorithm can be incorporated into various coalescent HMMs, including the popular method PSMC for inferring variable effective population sizes. Here we implement this algorithm to speed up our demographic inference method diCal, which is equivalent to PSMC when applied to a sample of two haplotypes. We demonstrate that the linear-time method can reconstruct a population size change history more accurately than the quadratic-time method, given similar computation resources. We also apply the method to data from the 1000 Genomes project, inferring a high-resolution history of size changes in the European population.

Keywords

Demographic inference effective population size coalescent with recombination expectation-maximization augmented hidden Markov model human migration out of Africa 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Kelley Harris
    • 1
  • Sara Sheehan
    • 2
  • John A. Kamm
    • 3
  • Yun S. Song
    • 2
    • 3
    • 4
  1. 1.Department of MathematicsUniversity of CaliforniaBerkeleyUSA
  2. 2.Computer Science DivisionUniversity of CaliforniaBerkeleyUSA
  3. 3.Department of StatisticsUniversity of CaliforniaBerkeleyUSA
  4. 4.Department of Integrative BiologyUniversity of CaliforniaBerkeleyUSA

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