From Polymers to Nanomedicines: New Materials for Future Vaccines

  • Philipp Heller
  • David Huesmann
  • Martin Scherer
  • Matthias BarzEmail author


Nanomedicine is the medical application of nanotechnology and therefore covers various kinds of nanoparticles. In this chapter, we would like to provide a brief introduction and overview of nanoparticles for the modulation of the immune system. In general, these nano-sized objects can be inorganic colloids, organic colloids (synthesized by emulsion polymerization or mini-/nanoemulsion techniques), polymeric aggregates (micelles or polymersomes), core cross-linked aggregates (nanohydrogels, crosslinked micelles, or polyplexes), multifunctional polymer coils, dendritic polymers or perfect dendrimers. A special focus is set on polymeric materials, because the chemical composition of the particle corona will shape particle properties by providing steric stabilization, avoiding protein adsorption and particle aggregation in vivo. Besides synthesis of new materials, particle characterization is equally important and might be the key to a more detailed understanding of the behavior of nano-sized systems. In addition, we would like to highlight approaches towards nanoparticle-based immunotherapies.


Block Copolymer West Nile Virus Atom Transfer Radical Polymerization Atom Transfer Radical Polymerization Lower Critical Solution Temperature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Philipp Heller
    • 1
  • David Huesmann
    • 1
  • Martin Scherer
    • 1
  • Matthias Barz
    • 1
    Email author
  1. 1.Institute of Organic ChemistryJohannes Gutenberg-University MainzMainzGermany

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