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Correlations Between Quantitative MR Imaging Properties and Viscoelastic Material Properties of Agarose Gel

  • Erica D. ChinEmail author
  • Jenny Ma
  • Christopher L. Lee
  • Hernan J. Jara
Conference paper
Part of the Conference Proceedings of the Society for Experimental Mechanics Series book series (CPSEMS)

Abstract

This study determines and assesses correlations between quantitative magnetic resonance imaging (qMRI) parameters (proton density, diffusion, T1 and T2 relaxation) and viscoelastic material properties (storage modulus) for various low concentrations (0.5–3.0 % weight/volume) of agarose gel. MR imaging was done using a 3T (Philips Achieva) scanner. Dynamic mechanical analysis (DMA) was used to characterize the viscoelastic properties of the gels. The repeatability and accuracy of the DMA measurements have some dependence on various geometric sample and measurement parameters. An optimal set of parameters (for compression mode testing) that would produce reliable and repeatable measurements was identified for ranges of sample geometry. Higher concentrations of agarose were associated with higher storage moduli and lower relaxation times, diffusion coefficients, and proton densities. Of the qMRI parameters, T2 relaxation is the most sensitive to changes in concentration.

Keywords

Agarose qMRI PD T1 T2 Storage modulus Magnetic resonance DMA 

Notes

Acknowledgements

The authors wish to acknowledge the contributions of Matthew Neal (Olin College) and Peter Kokias (PerkinElmer, Inc.).

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Copyright information

© The Society for Experimental Mechanics, Inc. 2014

Authors and Affiliations

  • Erica D. Chin
    • 1
    Email author
  • Jenny Ma
    • 1
  • Christopher L. Lee
    • 1
  • Hernan J. Jara
    • 2
  1. 1.Franklin W. Olin College of EngineeringNeedhamUSA
  2. 2.Department of RadiologyBoston University Medical CenterBostonUSA

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