A Workflow for the Application of Biclustering to Mass Spectrometry Data

  • Hugo López-FernándezEmail author
  • Miguel Reboiro-Jato
  • Sara C. Madeira
  • Rubén López-Cortés
  • J. D. Nunes-Miranda
  • H. M. Santos
  • Florentino Fdez-Riverola
  • Daniel Glez-Peña
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 222)


Biclustering techniques have been successfully applied to analyze microarray data and they begin to be applied to the analysis of mass spectrometry data, a high-throughput technology for proteomic data analysis which has been an active research area during the last years. In this work, we propose a novel workflow to the application of biclustering to MALDI-TOF mass spectrometry data, supported by a software desktop application which covering all of its stages. We evaluate the adequacy of applying biclustering to analyze mass spectrometry by comparing between biclustering and hierarchical clustering over two real datasets. Results are promising since they revealed the ability of these techniques to extract useful information, opening a door to further works.


biclustering mass spectrometry BiMS BiBit Bimax 


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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Hugo López-Fernández
    • 1
    Email author
  • Miguel Reboiro-Jato
    • 1
  • Sara C. Madeira
    • 2
  • Rubén López-Cortés
    • 3
  • J. D. Nunes-Miranda
    • 3
  • H. M. Santos
    • 3
  • Florentino Fdez-Riverola
    • 1
  • Daniel Glez-Peña
    • 1
  1. 1.ESEI: Escuela Superior de Ingeniería InformáticaUniversity of VigoOurenseSpain
  2. 2.Knowledge Discovery and Bioinformatics group (KDBIO), INESC-ID, Instituto Superior Técnico (IST)Technical University of LisbonLisbonPortugal
  3. 3.Bioscope Group, REQUIMTE, Departamento de Química, Faculdade de Ciencias e Tecnologia (FCT)Universidade Nova de LisboaCaparicaPortugal

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