Abstract
Proliferating synovial tissue with activated fibroblasts and inflammatory cell infiltration (lymphocytes, plasma cells, activated macrophages and dendritic cells) which intensively grows into the surrounding bone on the joint margin causing local osteolysis. The typical picture of bone erosion therefore develops. A frequent finding of multi-nucleated cells with phenotypic characteristics of osteoclasts in the interface between bone and pannus led to the presumption of direct involvement of the cells derived from the pannus in bone resorption. The focal inflammation in rheumatoid arth ritis affects subchondral and juxta-articular bone, where pannus development begins.
Keywords
Pancreatic Carcinoma Synovial Tissue Connective Tissue Disease Inflammatory Cell Infiltration Bone Erosion
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Copyright information
© Springer-Verlag/Wien 2009