Dictionary of Rheumatology pp 145-146 | Cite as
Non-steroidal anti-inflammatory drugs (NSAIDs) — clinical effect and indication
Chapter
Abstract
They are subject to common properties and these properties are very similar among different NSAIDs. After NSAID administration, relief of pain, stiffness and other symptoms occurs. Individual variations in the effectiveness of a particular NSAID can be explained by the pharmacokinetics of the drug at the cellular level. Various factors such as physical and chemical properties of the drug, pharmacokinetic parameters, the ability to inhibit a particular isoform of cyclooxygenase, selection of the form of application and the variability of the treated disease or symptom, all affect the variability of NSAID effectiveness (see table 6).
Table 6
Variability of NSAID effectiveness
| Physical and chemical | Lipid solubility |
| properties | |
| Pharmacokinetics | plasma half-life |
| Pharmacodynamics | selectivity of COX-2 |
| inhibition | |
| Dose selection and | chronopharmacology |
| application period | |
| Variability of disease | elimination organ |
| disorders | |
| Adverse effects, | idiosyncrasy |
| pharmacogenetic | |
| differences |
Keywords
Patent Ductus Arteriosus Mefenamic Acid Anthranilic Acid Reactive Arthritis Tiaprofenic Acid
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© Springer-Verlag/Wien 2009