Radiosurgery from the brain to the spine: 20 years experience

  • Antonio A. F. De Salles
  • A. A. Gorgulho
  • M. Selch
  • J. De Marco
  • N. Agazaryan
Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 101)



Radiosurgery evolved from brain to spine. Mechanical and computer advances in linear accelerator (LINAC) radiosurgery apply precise single/fractional stereotactic radiation to multiple pathologies.


During a 10-year span the senior author used proton-beam radiosurgery in over 300 lesions, followed by gamma-knife, adapted and dedicated LINACS, including cyber-knife, in another 700 patients. The last 10 years, experience was accumulated with the Novalis in over 3,000 patients. Novalis uses a beam-shaper in a high-speed delivery LINAC. It operates using conventional circular arc, conformai static beam, dynamic conformai or intensity modulated modes. Patients treated with Novalis at the UCLA since 1997 were evaluated regarding effectiveness, complications and failure. These results were compared with previous 1997 data.


Over 4,000 patients with trigeminal neuralgia/intractable pain, arteriovenous malformations/angiomas, métastases, ependymomas, gliomas, meningiomas hemangiopericytomas, schwannomas, adenomas, hemangioblastomas, and chordoma were treated. Spinal lesions were treated with frameless stereotaxis and on-line precision checks. Treatment was expeditious, comfortable and with reduced complications. Success is similar or superior to published data. Reduced treatment time of complex lesions and highly homogeneous dose compares favorably to other radiosurgery.


The senior author’s experience validates the novel shaped-beam approach. Long-term follow-up supports safety and effectiveness and capability to treat brain and spine.


Proton beam linear accelerator gamma-knife radiosurgery spine 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Antonio A. F. De Salles
    • 1
    • 2
  • A. A. Gorgulho
    • 1
  • M. Selch
    • 2
  • J. De Marco
    • 2
  • N. Agazaryan
    • 2
  1. 1.Division of Neurosurgery, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Radiation Oncology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA

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