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Transgenic rodent models of Parkinson’s disease

  • Conference paper
Reconstructive Neurosurgery

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 101))

Abstract

In the case of Parkinson’s disease (PD), classical animal models have utilized dopaminergic neurotoxins such as 6-hydroxydopamine (6OHDA) and 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP). More recently, human genetic linkage studies have identified several genes in familial forms of PD. Transgenic models have been made that explore the function of PD-linked genes (e.g. a-synuclein, DJ-1, LRRK2, Parkin, UCH-L1, PINK1). Recent evidence suggests mitochondrial dysfunction may play a major role in PD. Manipulation of mitochondrial respiratory genes (e.g. mitochondrial transcription factor A or TFAM) also elicits a PD phenotype in mice. Transgenic mice (MitoPark) were developed that have TFAM selectively knocked out in dopaminergic neurons. The nigral dopamine neurons of MitoPark mice show respiratory chain dysfunction, accompanied by the development of intraneuronal inclusions and eventual cell death. In early adulthood, the MitoPark mice show a slowly progressing loss of motor function that accompanies these cellular changes. The MitoPark mouse enables further study of the role of mitochondrial dysfunction in DA neurons as an important mechanism in the development of PD. Transgenic technology has allowed new insights into mechanisms of neurodegeneration for a number of neurological disorders. This paper will summarize recent studies on several transgenic models of PD.

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Authors and Affiliations

  1. Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 21224, Baltimore, MD, USA

    B. K. Harvey, Y. Wang & Barry J. Hoffer MD, PhD

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  1. B. K. Harvey
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  2. Y. Wang
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  3. Barry J. Hoffer MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.

    Wen-Ta Chiu

  2. Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.

    Yung-Hsiao Chiang

  3. Department of Neurosurgery, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan, R.O.C.

    Ming-Chien Kao  & Ching-Chang Hung  & 

  4. Center for Neuropsychiatry, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.

    Shinn-Zong Lin

  5. Department of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, R.O.C.

    Han-Jung Chen

  6. Department of Rehabilitation Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan, R.O.C.

    Simon F. T. Tang

  7. National Institute on Drug Abuse, National Institute of Health, Baltimore, USA

    Barry J. Hoffer

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© 2008 Springer-Verlag

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Harvey, B.K., Wang, Y., Hoffer, B.J. (2008). Transgenic rodent models of Parkinson’s disease. In: Chiu, WT., et al. Reconstructive Neurosurgery. Acta Neurochirurgica Supplementum, vol 101. Springer, Vienna. https://doi.org/10.1007/978-3-211-78205-7_15

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  • DOI: https://doi.org/10.1007/978-3-211-78205-7_15

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